广州化工
廣州化工
엄주화공
GUANGZHOU CHEMICAL INDUSTRY AND TECHNOLOGY
2014年
15期
13-16,33
,共5页
聚乳酸-聚乙二醇%嵌段聚合物%生物可降解性%药物载药系统
聚乳痠-聚乙二醇%嵌段聚閤物%生物可降解性%藥物載藥繫統
취유산-취을이순%감단취합물%생물가강해성%약물재약계통
PLA-PEG%block copolymer%biodegradability%drug delivery system
介绍了PLA嵌段PEG聚合物的合成、性质和质量评价方法，对其所形成的载药胶束的性能评价指标进行了总结，并综述了其作为胶束在药物载药系统中的应用，尤其是应用在抗肿瘤药物上的研究进展。结论： PLA嵌段PEG聚合物有良好的生物可降解性和相容性，为目前胶束载药系统中聚合物的研究热点，具有广泛应用前景。
介紹瞭PLA嵌段PEG聚閤物的閤成、性質和質量評價方法，對其所形成的載藥膠束的性能評價指標進行瞭總結，併綜述瞭其作為膠束在藥物載藥繫統中的應用，尤其是應用在抗腫瘤藥物上的研究進展。結論： PLA嵌段PEG聚閤物有良好的生物可降解性和相容性，為目前膠束載藥繫統中聚閤物的研究熱點，具有廣汎應用前景。
개소료PLA감단PEG취합물적합성、성질화질량평개방법，대기소형성적재약효속적성능평개지표진행료총결，병종술료기작위효속재약물재약계통중적응용，우기시응용재항종류약물상적연구진전。결론： PLA감단PEG취합물유량호적생물가강해성화상용성，위목전효속재약계통중취합물적연구열점，구유엄범응용전경。
Synthesis, properties as well as property assessment method of PLA block PEG copolymers were introduced , then the performance evaluations of the micelles formed by these copolymers were briefly reviewed , finally their applications for micelles in drug delivery system were summarized , especially in the field of anticancer drugs.PLA block PEG copolymers possessed good biodegradability and biocompatibility and were the current research focuses of micelles delivery system , which had widely application prospects.
