CAJ | 학술논문

目的：探讨胰腺癌患者联合检测血清糖抗原19-9（CA19-9）、癌胚抗原（CEA）、糖抗原125（CA125）及糖抗原242（CA242）的临床意义。方法选取2009年3月-2013年10月胰腺癌患者65例设为胰腺癌组，同期住院的良性胰腺病患者64例设为良性胰腺疾病组，同期健康体检者66例设为对照组。观察3组血清 CA19-9、CEA、CA125、CA242水平差异，及单项检测和联合检测这4项指标诊断胰腺癌的敏感性和特异性。结果胰腺癌组血清 CA19-9、CA125、CA242、CEA 水平均显著高于胰腺良性疾病患组和对照组（P ＜0．01）；联合检测4项指标的灵敏度为87．69％，特异度为91．54％。结论胰腺癌患者血清CA19-9、CEA、CA125、CA242表达水平显著上升，联合检测这4项指标对胰腺癌具有较高的诊断价值。
목적：탐토이선암환자연합검측혈청당항원19-9（CA19-9）、암배항원（CEA）、당항원125（CA125）급당항원242（CA242）적림상의의。방법선취2009년3월-2013년10월이선암환자65례설위이선암조，동기주원적량성이선병환자64례설위량성이선질병조，동기건강체검자66례설위대조조。관찰3조혈청 CA19-9、CEA、CA125、CA242수평차이，급단항검측화연합검측저4항지표진단이선암적민감성화특이성。결과이선암조혈청 CA19-9、CA125、CA242、CEA 수평균현저고우이선량성질병환조화대조조（P ＜0．01）；연합검측4항지표적령민도위87．69％，특이도위91．54％。결론이선암환자혈청CA19-9、CEA、CA125、CA242표체수평현저상승，연합검측저4항지표대이선암구유교고적진단개치。
Objective To explore the clinical significance of combined detection of serum carbohydrate antigen 19-9 (CA-19-9),carcinoembryonic antigen (CEA),carbohydrate antigen 125 (CA125)and carbohydrate antigen 242 (CA242)in patients with pancreatic cancer.Methods 65 patients with pancreatic cancer were designed as pancreatic cancer group,another 64 patients with benign pancreatic disease and 66 healthy people with physical examinations at the same period were designed as benign pancreatic disease group and control group respectively.Serum CA19-9,CEA, CA125 and CA242 levels were observed among 3 groups,and the single and combined detection of the sensitivity and specificity of above 4 diagnostic indexes in detecting pancreatic cancer were con-ducted.Results Serum CA19-9,CEA,CA125 and CA242 levels were significantly higher in pan-creatic cancer group than the other two groups (P <0.01),and the sensitivity and specificity of combined detection of above 4 indexes were 87.69% and 91.54% respectively.Conclusion Serum CA19-9,CEA,CA125 and CA242 levels increase significantly in patients with pancreatic cancer, and their combined detection has a higher diagnostic value.