CAJ | 학술논문

目的：探讨退行性心瓣膜病（DHVD）患者不同心功能分级时，脂联素（APN）、脑钠肽（BNP）、超敏 C 反应蛋白（hs-CRP）水平变化及其临床意义。方法按 NYHA 心功能分级将132例 DHVD 患者分为4组：心功能Ⅰ级组（A 组）、心功能Ⅱ级组（B 组）、心功能Ⅲ级组（C 组）、心功能Ⅳ级组（D 组）。检测所有患者血清 APN、BNP、hs-CRP 水平及左心室射血分数（LVEF），比较各组之间的差异。结果 DHVD 患者血清 APN、BNP、hs-CRP 水平随着心功能恶化而逐渐升高，每组间差异均有显著统计学意义（P ＜0．01）。APN、BNP、hs-CRP水平与LVEF呈负相关（r ＝-0．36，P ＜0．01；r ＝-0．42，P ＜0．01；r ＝-0．39，P ＜0．01）。结论 APN、BNP、hs-CRP 有助于 DHVD 患者心功能危险分层评价。
목적：탐토퇴행성심판막병（DHVD）환자불동심공능분급시，지련소（APN）、뇌납태（BNP）、초민 C 반응단백（hs-CRP）수평변화급기림상의의。방법안 NYHA 심공능분급장132례 DHVD 환자분위4조：심공능Ⅰ급조（A 조）、심공능Ⅱ급조（B 조）、심공능Ⅲ급조（C 조）、심공능Ⅳ급조（D 조）。검측소유환자혈청 APN、BNP、hs-CRP 수평급좌심실사혈분수（LVEF），비교각조지간적차이。결과 DHVD 환자혈청 APN、BNP、hs-CRP 수평수착심공능악화이축점승고，매조간차이균유현저통계학의의（P ＜0．01）。APN、BNP、hs-CRP수평여LVEF정부상관（r ＝-0．36，P ＜0．01；r ＝-0．42，P ＜0．01；r ＝-0．39，P ＜0．01）。결론 APN、BNP、hs-CRP 유조우 DHVD 환자심공능위험분층평개。
Objective To evaluate the serum levels of adiponectin(APN),B-type natri-uretic peptide(BNP),high sensitivity C-reactive protein (hs-CRP)and their clinical significance in patients with degenerative heart vascular disease (DHVD )according to different cardiac function classification.Methods According to New York Heart Association(NYHA),132 patients with DHVD were divided into NYHA class Ⅰ group(A group),NYHA class Ⅱ group (B group),NY-HA class Ⅲ group (C group),NYHA class Ⅳ group (D group).The serum levels of APN , BNP,hs-CRP were measured,left ventricular ejection fraction (LVEF)were determined by Doppler spectrum analysis.Results The serum levels of APN,BNP and hs-CRP levels signifi-cantly increased in patients with a higher class of NYHA (P <0.01).The serum APN,BNP and hs-CRPlevelswerenegativelycorrelatedwithLVEFinallpatients (r = -0 .3 6 ,P <0 .0 1 ;r =-0.42,P <0.01;r =-0.39,P <0.01).Conclusion The serum APN,BNP and hs-CRP levels are helpful in evaluating the changes in cardiac function of DHVD.