实用临床医药杂志
實用臨床醫藥雜誌
실용림상의약잡지
JOURNAL OF JIANGSU CLINICAL MEDICINE
2014年
16期
22-24
,共3页
2 型糖尿病%脑梗死%血管性假性血友病因子%糖化血红蛋白%血小板分布宽度%血小板体积
2 型糖尿病%腦梗死%血管性假性血友病因子%糖化血紅蛋白%血小闆分佈寬度%血小闆體積
2 형당뇨병%뇌경사%혈관성가성혈우병인자%당화혈홍단백%혈소판분포관도%혈소판체적
type 2 diabetes mellitus%cerebral infraction%von Willebrand factor%glcated hemoglobin%platelet distribution width%platelet volume
目的：探讨2型糖尿病并发脑梗死患者联合检测血浆血管性假性血友病因子（vWF）与血小板参数的临床价值。方法选取2011年12月-2013年10月2型糖尿病并发脑梗死患者32例，设为糖尿病并发脑梗死组，同期32例2型糖尿病患者设为糖尿病组，同期健康体检者30例设为对照组。检测3组糖化血红蛋白（HbA1c）、血 vWF 水平及血小板各参数，观察其差异及 HbA1c 与血 vWF 水平、血小板参数的关系。结果糖尿病并发脑梗死组、糖尿病组和对照组的 HbA1c、血 vWF 水平呈逐步下降趋势，组间比较有显著差异（P ＜0．01）。3组血小板计数（PLT）无显著差异（P ＞0．05）；血小板分布宽度（PDW）及血小板平均体积（MPV）在3组中呈逐步下降趋势，组间比较具有显著差异（P ＜0．01）；HbA1c 与 vWF、MPV、PDW 呈正相关（P ＜0．01）。结论2型糖尿病并发脑梗死患者血 vWF 水平显著升高，联合检测血 vWF 与血小板各参数可为早期诊断与治疗提供参考。
目的：探討2型糖尿病併髮腦梗死患者聯閤檢測血漿血管性假性血友病因子（vWF）與血小闆參數的臨床價值。方法選取2011年12月-2013年10月2型糖尿病併髮腦梗死患者32例，設為糖尿病併髮腦梗死組，同期32例2型糖尿病患者設為糖尿病組，同期健康體檢者30例設為對照組。檢測3組糖化血紅蛋白（HbA1c）、血 vWF 水平及血小闆各參數，觀察其差異及 HbA1c 與血 vWF 水平、血小闆參數的關繫。結果糖尿病併髮腦梗死組、糖尿病組和對照組的 HbA1c、血 vWF 水平呈逐步下降趨勢，組間比較有顯著差異（P ＜0．01）。3組血小闆計數（PLT）無顯著差異（P ＞0．05）；血小闆分佈寬度（PDW）及血小闆平均體積（MPV）在3組中呈逐步下降趨勢，組間比較具有顯著差異（P ＜0．01）；HbA1c 與 vWF、MPV、PDW 呈正相關（P ＜0．01）。結論2型糖尿病併髮腦梗死患者血 vWF 水平顯著升高，聯閤檢測血 vWF 與血小闆各參數可為早期診斷與治療提供參攷。
목적：탐토2형당뇨병병발뇌경사환자연합검측혈장혈관성가성혈우병인자（vWF）여혈소판삼수적림상개치。방법선취2011년12월-2013년10월2형당뇨병병발뇌경사환자32례，설위당뇨병병발뇌경사조，동기32례2형당뇨병환자설위당뇨병조，동기건강체검자30례설위대조조。검측3조당화혈홍단백（HbA1c）、혈 vWF 수평급혈소판각삼수，관찰기차이급 HbA1c 여혈 vWF 수평、혈소판삼수적관계。결과당뇨병병발뇌경사조、당뇨병조화대조조적 HbA1c、혈 vWF 수평정축보하강추세，조간비교유현저차이（P ＜0．01）。3조혈소판계수（PLT）무현저차이（P ＞0．05）；혈소판분포관도（PDW）급혈소판평균체적（MPV）재3조중정축보하강추세，조간비교구유현저차이（P ＜0．01）；HbA1c 여 vWF、MPV、PDW 정정상관（P ＜0．01）。결론2형당뇨병병발뇌경사환자혈 vWF 수평현저승고，연합검측혈 vWF 여혈소판각삼수가위조기진단여치료제공삼고。
Objective To explore the clinical significance of plasma vWF and platelet pa-rameters in patients with type 2 diabetes mellitus (T2DM)complicated with cerebral infraction. Methods A total of 32 patients with T2DM complicated with cerebral infraction from December 2011 to October 2013 and another 32 patients with single T2DM were selected as combination group and T2DM group,while another 30 healthy people served as control group.Glycated hemoglobin (HbA1c)level,von Willebrand factor (vWF)level and platelet parameters were detected in 3 groups to observe their differences and the relationship between HbA1c level and vWF level and platelet parameters were analyzed.Results HbA1c and vWF levels decreased gradually in combina-tion and T2DM groups than that in control group,and the differences were significant (P <0.01). There was no significant difference in platelet count (PLT)among 3 groups (P >0.05).However, platelet distribution width (PDW)and mean platelet volume (MPV)decreased evidently and gradu-ally in 3 groups (P <0.01).Additionally,HbA1c level was positive associated with vWF,PMV and PDW (P <0.01).Conclusion Level of vWF increases significantly in patients with T2DM complicated with cerebral infarction,whose detection combined with platelet parametes can provide references for the early diagnosis and treatment.
