CAJ | 학술논문

目的：分析动脉粥样硬化性脑梗死（ACI）与血浆脂蛋白相关性磷脂酶 A2（Lp-PLA2）、脂蛋白（a）[Lp（a）]水平的关系。方法采用彩色多普勒超声检查60例 ACI 患者颈部血管，评估颈部斑块稳定性；同时应用双抗体夹心酶联免疫吸附法（ELISA）检测脑梗死患者和健康体检患者的血浆 Lp-PLA2、Lp（a）水平；使用美国国立卫生研究院卒中量表（NIHSS）进行神经功能缺损程度评估。结果60例 ACI 患者中易损斑块44例，稳定斑块16例；ACI 患者的血浆 Lp-PLA2、Lp（a）均显著高于正常对照组（P ＜0．05）；易损斑块组的 Lp-PLA2、Lp（a）明显高于稳定斑块组（P ＜0．05）；神经功能缺损程度与血浆 Lp-PLA2水平无显著相关性（P ＞0．05）。结论 Lp-PLA2、Lp（a）升高与动脉粥样硬化性脑梗死密切相关，临床上可通过测定 Lp-PLA2、Lp （a）水平来预测脑梗死的发病风险，对预防及有效减少脑梗死复发具有重要意义。
목적：분석동맥죽양경화성뇌경사（ACI）여혈장지단백상관성린지매 A2（Lp-PLA2）、지단백（a）[Lp（a）]수평적관계。방법채용채색다보륵초성검사60례 ACI 환자경부혈관，평고경부반괴은정성；동시응용쌍항체협심매련면역흡부법（ELISA）검측뇌경사환자화건강체검환자적혈장 Lp-PLA2、Lp（a）수평；사용미국국립위생연구원졸중량표（NIHSS）진행신경공능결손정도평고。결과60례 ACI 환자중역손반괴44례，은정반괴16례；ACI 환자적혈장 Lp-PLA2、Lp（a）균현저고우정상대조조（P ＜0．05）；역손반괴조적 Lp-PLA2、Lp（a）명현고우은정반괴조（P ＜0．05）；신경공능결손정도여혈장 Lp-PLA2수평무현저상관성（P ＞0．05）。결론 Lp-PLA2、Lp（a）승고여동맥죽양경화성뇌경사밀절상관，림상상가통과측정 Lp-PLA2、Lp （a）수평래예측뇌경사적발병풍험，대예방급유효감소뇌경사복발구유중요의의。
Objective To analyze the relationship between plasma lipoprotein-associated phospholipase A2,lipoprotein(a)and atherosclerotic cerebral infraction(ACI).Methods The carotid plaque stability of 60 cerebral infraction patients were determined by cervical vascular color Doppler ultrasound.Plasma Lp-PLA2 and Lp(a)levels were detected by enzyme linked immunosor-bent assay(ELISL).Scores of neurological impairment were assessed by the National Institute of Health Stroke Scale (NIHSS).Results 44 patients with ACI showed unstable carotid plaques, while 16 patients with ACI showed stable carotid plaques.Compared with control group,the levels of plasma Lp-PLA2 and Lp(a)were higher in ACI group (P <0.05).The levels of plasma Lp-PLA2 and Lp (a )in unstable plaque group were higher than those in stable plaque group (P <0.05).The plasma level of Lp-PLA2 was negatively correlated with neurological impairment (P >0.05).Conclusion Increasing of Lp-PLA2 and Lp(a)are closely related with atherosclerotic cere-bral infarction.In clinic,the risk of cerebral infarction can be predicted by detecting the levels of Lp-PLA2 and LP(a),and it can play an important role in preventing and reducing the recurrence of cerebral infarction.