中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
17期
2621-2623
,共3页
金素芳%周晓梅%方锦川%郭玉萍
金素芳%週曉梅%方錦川%郭玉萍
금소방%주효매%방금천%곽옥평
糖尿病,妊娠%肝细胞生长因子%膜蛋白质类%预后
糖尿病,妊娠%肝細胞生長因子%膜蛋白質類%預後
당뇨병,임신%간세포생장인자%막단백질류%예후
Diabetes,gestational%Hepatocyte growth factor%Membrane proteins%Prognosis
目的:探讨妊娠期糖尿病( GDM)胎盘中肝细胞生长因子( HGF)、晚期糖基化终产物受体( RAGE)的表达及与母儿预后的关系。方法选择晚孕GDM孕妇63例,依据是否规律降血糖治疗分为治疗组40例,未治疗组23例,另选择同期产检并分娩的健康孕妇30例为对照组。采用免疫组织化学方法测定三组胎盘中HGF和RAGE的表达,并比较其母儿预后的差异。结果 HGF和RAGE在三组胎盘组织中均有表达,HGF在未治疗组、治疗组、对照组胎盘中表达逐渐增强,阳性单位(PU值)分别为(5.03±1.05)、(7.83±1.62)、(11.54±2.62),组间比较差异有统计学意义(F=7.56,P<0.05);RAGE在未治疗组、治疗组、对照组胎盘组织中表达逐渐减弱,PU值分别为(14.56±2.70)、(12.87±2.63)、(8.39±1.56),组间比较差异有统计学意义(F=11.62,P<0.05);未治疗组母、儿并发症发生率(178.26%、121.73%)均明显高于治疗组(65.00%、32.50%)和对照组(13.33%、3.33%),组间比较差异均有统计学意义(χ2=7.34、13.21、9.75、6.67、15.23、12.53,均P<0.05)。结论 HGF、RAGE可能参与了GDM的发生发展,与母儿预后关系密切,规律治疗可改善母儿预后。
目的:探討妊娠期糖尿病( GDM)胎盤中肝細胞生長因子( HGF)、晚期糖基化終產物受體( RAGE)的錶達及與母兒預後的關繫。方法選擇晚孕GDM孕婦63例,依據是否規律降血糖治療分為治療組40例,未治療組23例,另選擇同期產檢併分娩的健康孕婦30例為對照組。採用免疫組織化學方法測定三組胎盤中HGF和RAGE的錶達,併比較其母兒預後的差異。結果 HGF和RAGE在三組胎盤組織中均有錶達,HGF在未治療組、治療組、對照組胎盤中錶達逐漸增彊,暘性單位(PU值)分彆為(5.03±1.05)、(7.83±1.62)、(11.54±2.62),組間比較差異有統計學意義(F=7.56,P<0.05);RAGE在未治療組、治療組、對照組胎盤組織中錶達逐漸減弱,PU值分彆為(14.56±2.70)、(12.87±2.63)、(8.39±1.56),組間比較差異有統計學意義(F=11.62,P<0.05);未治療組母、兒併髮癥髮生率(178.26%、121.73%)均明顯高于治療組(65.00%、32.50%)和對照組(13.33%、3.33%),組間比較差異均有統計學意義(χ2=7.34、13.21、9.75、6.67、15.23、12.53,均P<0.05)。結論 HGF、RAGE可能參與瞭GDM的髮生髮展,與母兒預後關繫密切,規律治療可改善母兒預後。
목적:탐토임신기당뇨병( GDM)태반중간세포생장인자( HGF)、만기당기화종산물수체( RAGE)적표체급여모인예후적관계。방법선택만잉GDM잉부63례,의거시부규률강혈당치료분위치료조40례,미치료조23례,령선택동기산검병분면적건강잉부30례위대조조。채용면역조직화학방법측정삼조태반중HGF화RAGE적표체,병비교기모인예후적차이。결과 HGF화RAGE재삼조태반조직중균유표체,HGF재미치료조、치료조、대조조태반중표체축점증강,양성단위(PU치)분별위(5.03±1.05)、(7.83±1.62)、(11.54±2.62),조간비교차이유통계학의의(F=7.56,P<0.05);RAGE재미치료조、치료조、대조조태반조직중표체축점감약,PU치분별위(14.56±2.70)、(12.87±2.63)、(8.39±1.56),조간비교차이유통계학의의(F=11.62,P<0.05);미치료조모、인병발증발생솔(178.26%、121.73%)균명현고우치료조(65.00%、32.50%)화대조조(13.33%、3.33%),조간비교차이균유통계학의의(χ2=7.34、13.21、9.75、6.67、15.23、12.53,균P<0.05)。결론 HGF、RAGE가능삼여료GDM적발생발전,여모인예후관계밀절,규률치료가개선모인예후。
Objective To study the expression of HGF , RAGE in placentas of patients with gestational diabetes mellitus and its relationship with maternal and neonatal prognosis .Methods The complete clinical datas of late pregnancy,GDM treated group 40 cases,GDM untreated group 23 cases,the control group 30 cases.Immunohisto-chemical method was used to detect HGF and RAGE in the placentas of three groups ,the maternal and neonatal prog-nosis were recorded.Results In GDM untreated group,GDM treated group and the controlled group placenta ,HGF and RAGE expressed.The expression of HGF was gradually increased ,and any comparative differences between two groups were statistically significant ( F =7.56, P <0.05 );the expression of RAGE in placentas was gradually declined ,the differences among the control group and GDM untreated ,GDM treated group were statistically significant (F=11.62,P<0.05).The rates of maternal and neonatal complications in the GDM untreated group were signifi-cantly higher than that of the GDM treated group and the control group (χ2 =7.34,13.21,9.75,6.67,15.23, 12.53,all P<0.05).Conclusion HGF and RAGE may participate in the occurrence and development of GDM and maternal and neonatal prognosis closely ,regular treatment can improve the prognosis of mothers and infants .