中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
17期
2593-2595
,共3页
肝炎疫苗,乙型%免疫%新生儿筛查
肝炎疫苗,乙型%免疫%新生兒篩查
간염역묘,을형%면역%신생인사사
Hepatitis B vaccines%Immunity%Neonatal screening
目的：探讨婴儿接种乙型肝炎疫苗的免疫效果及低、无应答者再免疫效果。方法筛查松滋市妇幼保健院2000例7～12个月婴儿乙型肝炎疫苗初次免疫（初免）的效果，分析影响初免的因素，对初免低或无应答婴儿选择10μg汉逊酵母乙型肝炎疫苗或5μg重组酵母乙型肝炎疫苗进行再次接种（再免），分析再免1、3次后的效果。结果（1）2000例婴儿乙型肝炎疫苗初免应答率为92．2％，平均抗-HBs几何抗体浓度（GMC）为：（321．88±100．45）IU/L，其中父母HBsAg阳性和在乡镇医院出生的婴儿应答率较低，与父母HBsAg阴性和在县级以上医院出生的婴儿差异均有统计学意义（χ2＝30．61、47．58，均P＜0．05）。（2）两种疫苗再免1次、3次GMC含量均比再免前增高，差异均有统计学意义（t＝98．32、102．15，均P＜0．05）；再免3次较再免1次应答率及GMC含量高，差异均有统计学意义（t＝98．55、102．33，均P＜0．05）；汉逊酵母乙肝疫苗再免1次、3次后GMC含量较高，与重组酵母乙型肝炎疫苗差异均有统计学意义（ t＝104．11、124．31，均P＜0．05）。结论父母HBsAg阳性和在基层医院出生的婴儿低、无应答比例较高，再免后应答率较高，汉逊酵母乙型肝炎疫苗效果较好。
目的：探討嬰兒接種乙型肝炎疫苗的免疫效果及低、無應答者再免疫效果。方法篩查鬆滋市婦幼保健院2000例7～12箇月嬰兒乙型肝炎疫苗初次免疫（初免）的效果，分析影響初免的因素，對初免低或無應答嬰兒選擇10μg漢遜酵母乙型肝炎疫苗或5μg重組酵母乙型肝炎疫苗進行再次接種（再免），分析再免1、3次後的效果。結果（1）2000例嬰兒乙型肝炎疫苗初免應答率為92．2％，平均抗-HBs幾何抗體濃度（GMC）為：（321．88±100．45）IU/L，其中父母HBsAg暘性和在鄉鎮醫院齣生的嬰兒應答率較低，與父母HBsAg陰性和在縣級以上醫院齣生的嬰兒差異均有統計學意義（χ2＝30．61、47．58，均P＜0．05）。（2）兩種疫苗再免1次、3次GMC含量均比再免前增高，差異均有統計學意義（t＝98．32、102．15，均P＜0．05）；再免3次較再免1次應答率及GMC含量高，差異均有統計學意義（t＝98．55、102．33，均P＜0．05）；漢遜酵母乙肝疫苗再免1次、3次後GMC含量較高，與重組酵母乙型肝炎疫苗差異均有統計學意義（ t＝104．11、124．31，均P＜0．05）。結論父母HBsAg暘性和在基層醫院齣生的嬰兒低、無應答比例較高，再免後應答率較高，漢遜酵母乙型肝炎疫苗效果較好。
목적：탐토영인접충을형간염역묘적면역효과급저、무응답자재면역효과。방법사사송자시부유보건원2000례7～12개월영인을형간염역묘초차면역（초면）적효과，분석영향초면적인소，대초면저혹무응답영인선택10μg한손효모을형간염역묘혹5μg중조효모을형간염역묘진행재차접충（재면），분석재면1、3차후적효과。결과（1）2000례영인을형간염역묘초면응답솔위92．2％，평균항-HBs궤하항체농도（GMC）위：（321．88±100．45）IU/L，기중부모HBsAg양성화재향진의원출생적영인응답솔교저，여부모HBsAg음성화재현급이상의원출생적영인차이균유통계학의의（χ2＝30．61、47．58，균P＜0．05）。（2）량충역묘재면1차、3차GMC함량균비재면전증고，차이균유통계학의의（t＝98．32、102．15，균P＜0．05）；재면3차교재면1차응답솔급GMC함량고，차이균유통계학의의（t＝98．55、102．33，균P＜0．05）；한손효모을간역묘재면1차、3차후GMC함량교고，여중조효모을형간염역묘차이균유통계학의의（ t＝104．11、124．31，균P＜0．05）。결론부모HBsAg양성화재기층의원출생적영인저、무응답비례교고，재면후응답솔교고，한손효모을형간염역묘효과교호。
Objective To investigate the immune effect of neonatal hepatitis B vaccination and its once more immune effect in low or no responders .Methods Screening Songzi city MCH 2 000 cases of hepatitis B vaccine 7-12 months baby's first immunization effect ,analyze the impact of the prime factors for early response in children with low or no free choice 10μg Hansenula yeast recombinant hepatitis B vaccine or 5μg hepatitis B vaccine ( HepB-SC) , carried revaccination(Immune again),then analyzed the effect of free 1,3 times.Results (1) Primary immune response rate of neonatal hepatitis B vaccine in 2 000 cases was 92.2%,the average anti-HBsGMC was (321.88 ± 100.45) IU/L,in which the HBsAg positive persons and birth in the township hospital neonatal response rate was low that had a statistically significant (χ2 =30.61,47.58,all P <0.05) difference with the children whose parents'HBsAg was negative and borned in hospitals above the county level;( 2 ) GMC content was increase in once more immune at 1,3 times than before,the difference was statistically significant (t=98.32,102.15,all P<0.05),and the 3 time is higher than the 1 time once more immuneof levels of GMC ,the difference was statistically significant ( t=98.55,102.33,all P<0.05),content of GMC is higher in once more immune of Hansenula hepatitis B vaccine at 1, 3 times when compared with the recombinant hepatitis B vaccine , the difference was statistically significant ( t =104.11,124.31,all P<0.05).Conclusion Low and non-responders'proportion is high in the children whose par-ents'HBsAg is positive and be born in the primary hospital ,which has a higher response rate after once more immune , Hansenula hepatitis B vaccine has a better immune effect .
