CAJ | 학술논문

目的：研究高危型人乳头瘤病毒（ HPV）含量与子宫颈癌前病变（ CIN）的关系。方法选取CIN患者450例为观察组，另以同期450例健康妇女为对照组，检测并比较两组不同高危型HPV DNA阳性率及含量，并将观察组中不同CIN分级者的检测结果用Logistic分析其与CIN的关系。结果观察组中不同高危型HPV DNA阳性率分别为9．11％、6．67％、6．67％、6．67％及6.00％，均高于对照组（χ2＝6．871、6．240、6.240、6．240、5．871，均P＜0．05），且不同CIN分级者的阳性率差异也有统计学意义（均P＜0．05）；观察组的病毒含量及低、中、高度构成比分别为（301．35±32．67） Copies/mL和11．56％、10．22％、9.56％，均明显高于对照组（t＝6．276，χ2＝7．132、6．915、5．878，均P＜0．05），且不同分级者的含量差异均有统计学意义（均P＜0．05），经Logistic分析显示，其与CIN有密切的关系（OR值为3．805，P＜0．05）。结论 CIN患者高危型HPV病毒含量呈现异常的状态，经分析其与疾病有密切的关系。
목적：연구고위형인유두류병독（ HPV）함량여자궁경암전병변（ CIN）적관계。방법선취CIN환자450례위관찰조，령이동기450례건강부녀위대조조，검측병비교량조불동고위형HPV DNA양성솔급함량，병장관찰조중불동CIN분급자적검측결과용Logistic분석기여CIN적관계。결과관찰조중불동고위형HPV DNA양성솔분별위9．11％、6．67％、6．67％、6．67％급6.00％，균고우대조조（χ2＝6．871、6．240、6.240、6．240、5．871，균P＜0．05），차불동CIN분급자적양성솔차이야유통계학의의（균P＜0．05）；관찰조적병독함량급저、중、고도구성비분별위（301．35±32．67） Copies/mL화11．56％、10．22％、9.56％，균명현고우대조조（t＝6．276，χ2＝7．132、6．915、5．878，균P＜0．05），차불동분급자적함량차이균유통계학의의（균P＜0．05），경Logistic분석현시，기여CIN유밀절적관계（OR치위3．805，P＜0．05）。결론 CIN환자고위형HPV병독함량정현이상적상태，경분석기여질병유밀절적관계。
Objective To study the relationship between the virus content of high risk HPV and cervical intraepithelial neoplasia(CIN).Methods 450 patients with cervical intraepithelial neoplasia (CIN) were selected as the observation group ,450 healthy women at the same time were the control group ,then the positive rate and content of the control group and observation group with different high risk HPV types were detected and compared ,then the detection results of observation group with different CIN classification were compared too ,and the relationship of the detection indexes between the CIN were analyzed by the Logistic analysis .Results The HPV DNA positive rate of observation group with different high risk types were 9.11%,6.67%,6.67%,6.67%and 6.00%,respectively,and they were all higher than those of control group (χ2 =6.871,6.240,6.240,6.240,5.871,all P<0.05),and the positive rate of patients with different CIN classification had obvious differences too ,the virus content and constitution of observation group were respectively (301.35 ±32.67) Copies/mL and 11.56%,10.22%,9.56%,and they were all obviously higher than those of control group (t=6.276,χ2 =7.132,6.915,5.878,all P<0.05),and the content of patients with different classification had obvious differences ,all P<0.05,there were all significant differences ,and the item had close relationship to CIN by the Logistic analysis .Conclusion The high risk HPV virus content of patients with cervical intraepithelial neoplasia shows abnormal state ,and which have close relationship to the disease .