CAJ | 학술논문

目的：观察急性肾盂肾炎应用左氧氟沙星的临床干预效果。方法将我院2010年4月~2013年11月确诊并收治的110例急性肾盂肾炎患者随机分为临床组和参照组各55例。临床组应用左氧氟沙星静脉滴注进而口服治疗，参照组应用氨苄青霉素静脉滴注治疗进而用磺胺甲恶唑口服治疗。比照两组症状体征消失时间、临床疗效及治疗时间。结果两组用药完成后，症状体征逐渐改善，临床组其症状体征消失速度均显著好于参照组，差异有统计学意义（P＜0.05）。临床组总有效率为98.18%，参照组为96.36%，两组比较差异无统计学意义（P＞0.05）。但临床组其平均治疗时长显著低于参照组，差异有统计学意义（P＜0.05）。临床组1例发生恶心、呕吐，1例头晕，1例皮肤瘙痒；参照组4例发生恶心、呕吐。两组相比不良反应率差异无统计学意义（P＞0.05）。结论急性肾盂肾炎应用左氧氟沙星疗效确切，迅速缓解症状体征、疗程短、安全性好。
목적：관찰급성신우신염응용좌양불사성적림상간예효과。방법장아원2010년4월~2013년11월학진병수치적110례급성신우신염환자수궤분위림상조화삼조조각55례。림상조응용좌양불사성정맥적주진이구복치료，삼조조응용안변청매소정맥적주치료진이용광알갑악서구복치료。비조량조증상체정소실시간、림상료효급치료시간。결과량조용약완성후，증상체정축점개선，림상조기증상체정소실속도균현저호우삼조조，차이유통계학의의（P＜0.05）。림상조총유효솔위98.18%，삼조조위96.36%，량조비교차이무통계학의의（P＞0.05）。단림상조기평균치료시장현저저우삼조조，차이유통계학의의（P＜0.05）。림상조1례발생악심、구토，1례두훈，1례피부소양；삼조조4례발생악심、구토。량조상비불량반응솔차이무통계학의의（P＞0.05）。결론급성신우신염응용좌양불사성료효학절，신속완해증상체정、료정단、안전성호。
ObjectiveTo investigate the clinical intervention effects of levofloxacin on acute pyelonephritis. Methods110 patients with acute pyelonephritis who were treated in our hospital from April 2010 to November 2013 were randomly divided into the clinical group and the reference group, with 55 patients in each group. The clinical group received intravenous drip of levofloxacin and then oral administration; The reference group received intravenous drip of penbritin and then oral administration of sulfamethoxazole. The symptom and sign disappearance time, clinical efficacy and treatment time of the two groups were compared.ResultsAfter the end of medication, the symptoms and sings improved gradually. The clinical group was significantly better than the reference group in both symptom and sign disappearance time, with statistically significant differences (P<0.05). The total effective rate of the clinical group was 98.18% and that of the reference group was 96.36%, with no statistically significant difference between the two groups (P>0.05). But the clinical group had significantly shorter average treatment duration than the reference group (P<0.05), with statistically significant difference. In the clinical group, 1 patient had nausea and vomiting, 1 patient had dizziness, and 1 patient had skin itch; In the reference group, 4 patients had nausea and vomiting. The two groups were not significantly different in the incidence of adverse reactions (P>0.05). ConclusionIn the treatment of acute pyelonephritis, the application of levofloxacin shows accurate efficacy, relieves symptoms and signs rapidly, and has short treatment course and good safety.