中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
16期
42-43
,共2页
合成%美沙拉嗪%5-胺基-2-羟基苯甲酸%方法改进
閤成%美沙拉嗪%5-胺基-2-羥基苯甲痠%方法改進
합성%미사랍진%5-알기-2-간기분갑산%방법개진
Synthesis%Mesalazine%5-Aminosalicylic acid%Improvement methods
目的：探讨药物化学实验合成美沙拉嗪的改进方法。方法通过改进实验方法，以水杨酸为原料，控制硝酸硝化反应，在酸性条件下以锌粉和铁粉混合交替添加的办法进行硝基还原。结果第一步反应得到5-硝基水杨酸收率为65%，美沙拉嗪的总收率为39%。结论改进后的合成方法简单，实验结果可靠，便于学生学习和掌握，可提高教学效果和质量。
目的：探討藥物化學實驗閤成美沙拉嗪的改進方法。方法通過改進實驗方法，以水楊痠為原料，控製硝痠硝化反應，在痠性條件下以鋅粉和鐵粉混閤交替添加的辦法進行硝基還原。結果第一步反應得到5-硝基水楊痠收率為65%，美沙拉嗪的總收率為39%。結論改進後的閤成方法簡單，實驗結果可靠，便于學生學習和掌握，可提高教學效果和質量。
목적：탐토약물화학실험합성미사랍진적개진방법。방법통과개진실험방법，이수양산위원료，공제초산초화반응，재산성조건하이자분화철분혼합교체첨가적판법진행초기환원。결과제일보반응득도5-초기수양산수솔위65%，미사랍진적총수솔위39%。결론개진후적합성방법간단，실험결과가고，편우학생학습화장악，가제고교학효과화질량。
Objective To study the improvement synthesis methods of mesalazine in pharmaceutical chemistry experiments.MethodsUsing salicylic acid as raw material, improving the methods by controlling the nitration reaction, zinc powder and iron powder with 5-nitro salicylic acid were added alternately under acid condition to reduce nitro group to amino group. ResultsThe 5-nitro salicylic acid yield was 65% in the first step, and the total yield of mesalazine was 39%.ConclusionThe improved synthesis method is simple and the results is reliable, which can facilitate students to learn and master, and improve the teaching effect and quality.
