CAJ | 학술논문

目的：研究高脂饮食喂养小鼠内脏脂肪和皮下脂肪组织中PAI-1、FOXC2及FOXO1表达水平，探讨不同类型肥胖的机制。方法20只小鼠随机分为对照组和高脂组，分别给予正常饮食和高脂饮食喂养12周。测定血清PAI-1以及附睾周围组织及皮下脂肪中PAI-1、FOXC2及FOXO1 mRNA的表达水平。结果高脂组小鼠体质量、血清PAI-1水平均显著高于对照组。组内比较小鼠附睾周围脂肪组织PAI-1、FOXC2mRNA表达显著高于皮下脂肪组织；FOXO1mRNA表达显著低于于皮下脂肪组织，差异有统计学意义。结论正常体重小鼠和肥胖小鼠血清PAI-1水平表达不同，内脏脂肪和皮下脂肪PAI-1、FOXC2及FOXO1表达也存在差别，这种差别可能是不同类型肥胖的机制之一。
목적：연구고지음식위양소서내장지방화피하지방조직중PAI-1、FOXC2급FOXO1표체수평，탐토불동류형비반적궤제。방법20지소서수궤분위대조조화고지조，분별급여정상음식화고지음식위양12주。측정혈청PAI-1이급부고주위조직급피하지방중PAI-1、FOXC2급FOXO1 mRNA적표체수평。결과고지조소서체질량、혈청PAI-1수평균현저고우대조조。조내비교소서부고주위지방조직PAI-1、FOXC2mRNA표체현저고우피하지방조직；FOXO1mRNA표체현저저우우피하지방조직，차이유통계학의의。결론정상체중소서화비반소서혈청PAI-1수평표체불동，내장지방화피하지방PAI-1、FOXC2급FOXO1표체야존재차별，저충차별가능시불동류형비반적궤제지일。
Objective To study the expression level of PAI-1, FOXC2 and FOXO1 in high fat diet of visceral fat and subcutaneous fat tissue,and to investigate the mechanism of different types of obesity.Methods 20 mouse were randomLy divided into control group and high fat group, and given normal diet and high fat diet for 12 weeks. Serum PAI-1,the expression level of PAI-1, FOXC2 and FOXO1 mRNA in epididymal tissue and subcutaneous fat were determined. Results The body weight, serum PAI-1 levels of high fat group were significantly higher than those of the control group. Within the group, PAI-1,FOXC2, mRNA expression of mouse epididymal adipose tissue were significantly higher than those of the subcutaneous adipose tissue, and the expression of FOXO1mRNA of mouse epididymal adipose tissue was significantly lower than that of subcutaneous adipose tissue, with statistical significance difference. Conclusion Expression levels of serum PAI-1 are different between normal weight mice and obese mice,and expression of fat PAI-1, FOXC2and FOXO1 in visceral fat and subcutaneous are also different. This difference may be one of the mechanisms of different types of obesity.