CAJ | 학술논문

目的：探讨不同剂量布地奈德混悬液氧气雾化对慢性阻塞性肺疾病的疗效比较，旨在提高治疗效果。方法收集2011年4月～2013年11月我科住院的420例稳定期COPD患者及330例急性加重期COPD患者，将稳定期慢性阻塞性肺疾病（COPD）患者分为中等剂量组、小剂量组、对照组。急性加重期慢性阻塞性肺疾病（AECOPD）患者被分为大剂量组、中剂量组、一般剂量组以及对照组。对比分析各组间的治疗效果、肺功能和生活质量。结果稳定期患者治疗后中等剂量组、小剂量组呼吸困难评分与对照组比较评分均明显改善（P＜0.05），中等剂量组FEV1、FEV1/FVC（%）与小剂量组与对照组比较差异有统计学意义（ P＜0.05）。患者生活质量评分中等剂量组、小剂量组与对照组比较差异有统计学意义（P ＜0.05）。AECOPD患者在治疗5、10d后三组肺功能均有明显改善，不同剂量组间均有显著性差异（P＜0.05）。结论对于稳定期COPD应用小剂量布地奈德雾化治疗，疗效肯定，无明显毒副作用，可以临床推广。急性发作期COPD，应用大剂量布地奈德雾化吸入可以使肺功能改善更快更好，且临床应用安全有效。
목적：탐토불동제량포지내덕혼현액양기무화대만성조새성폐질병적료효비교，지재제고치료효과。방법수집2011년4월～2013년11월아과주원적420례은정기COPD환자급330례급성가중기COPD환자，장은정기만성조새성폐질병（COPD）환자분위중등제량조、소제량조、대조조。급성가중기만성조새성폐질병（AECOPD）환자피분위대제량조、중제량조、일반제량조이급대조조。대비분석각조간적치료효과、폐공능화생활질량。결과은정기환자치료후중등제량조、소제량조호흡곤난평분여대조조비교평분균명현개선（P＜0.05），중등제량조FEV1、FEV1/FVC（%）여소제량조여대조조비교차이유통계학의의（ P＜0.05）。환자생활질량평분중등제량조、소제량조여대조조비교차이유통계학의의（P ＜0.05）。AECOPD환자재치료5、10d후삼조폐공능균유명현개선，불동제량조간균유현저성차이（P＜0.05）。결론대우은정기COPD응용소제량포지내덕무화치료，료효긍정，무명현독부작용，가이림상추엄。급성발작기COPD，응용대제량포지내덕무화흡입가이사폐공능개선경쾌경호，차림상응용안전유효。
ObjectiveTo investigate the efficacy of different doses budesonide on chronic obstructive pulmonary disease, aimed at improving the therapeutic effect.Methods420 stable COPD patients and 330 cases of acute COPD patients treated in our hospital from 2011.04 to 2013.11 were enrolled. the stable COPD patients were divided into moderate doses group, low-dose group and the control group . The AECOPD patients were divided into high-dose group, middle dose group, generally dose group and the control group. Comparative analysis of the therapeutic effect, pulmonary function and quality of life in different groups.Results The dyspnea scores of stable patients in moderate-dose group and low-dose group were significantly improved compared with control group (P<0.05). the difference of FEV1 and FEV1/FVC% in medium- dose group, low dose group and the control group was statistically significant after treatment (P<0.05) . The difference of QOL scores was statistically significant in moderate dose group, low -dose group and the control group (P<0.05). The lung function of AECOPD patients in three groups showed significant improvement after treatment of 5 days and 10 days (P<0.05).Conclusion For stable COPD patients, small dose of budesonide was more effective, without significant side effects, can be widely used clinical. For AECOPD, large doses of budesonide inhalation can make faster and better improvement in lung function. And it is safe and effective in clinical application.