中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
19期
2902-2904
,共3页
生长激素%体外受精%卵巢反应不良%胰岛素样生长因子I%胰岛素样生长因子结合蛋白3
生長激素%體外受精%卵巢反應不良%胰島素樣生長因子I%胰島素樣生長因子結閤蛋白3
생장격소%체외수정%란소반응불량%이도소양생장인자I%이도소양생장인자결합단백3
Growth hormone%IVF-ET%COH%IGF-I%IGFBP-3
目的：观察重组人生长激素（GH）在行体外受精-胚胎移植（IVF-ET）超促排卵过程中，对卵巢反应不良患者治疗效果的影响。方法将行IVF/CSI治疗的80例卵巢反应不良患者按数字表法随机分为两组：加用GH的为观察组（40例），未用GH的为对照组（40例），观察其促性腺激素使用总量及天数、获卵数及成熟卵母细胞数、受精率、卵裂率、获胚胎数目、优质胚胎数以及妊娠率，并应用ELISA法检测血清胰岛素样生长因子I（IGF-I）、胰岛素样生长因子结合蛋白3（IGFBP-3）的浓度，比较其差异。结果观察组使用促性腺激素量及天数、获卵数及成熟卵母细胞数、卵裂率、获胚胎数目、优质胚胎数均对照组，但差异均无统计学意义（均P＞0.05）；两组血清IGFBP-3浓度差异无统计学意义；两组受精率、妊娠率以及血清IGF-I浓度差异均有统计学意义（均P＜0．05）。结论合用GH可改善卵巢反应不良患者IVF-ET的结局，其机制与提高血清IGF-I浓度、改善卵子质量有关。
目的：觀察重組人生長激素（GH）在行體外受精-胚胎移植（IVF-ET）超促排卵過程中，對卵巢反應不良患者治療效果的影響。方法將行IVF/CSI治療的80例卵巢反應不良患者按數字錶法隨機分為兩組：加用GH的為觀察組（40例），未用GH的為對照組（40例），觀察其促性腺激素使用總量及天數、穫卵數及成熟卵母細胞數、受精率、卵裂率、穫胚胎數目、優質胚胎數以及妊娠率，併應用ELISA法檢測血清胰島素樣生長因子I（IGF-I）、胰島素樣生長因子結閤蛋白3（IGFBP-3）的濃度，比較其差異。結果觀察組使用促性腺激素量及天數、穫卵數及成熟卵母細胞數、卵裂率、穫胚胎數目、優質胚胎數均對照組，但差異均無統計學意義（均P＞0.05）；兩組血清IGFBP-3濃度差異無統計學意義；兩組受精率、妊娠率以及血清IGF-I濃度差異均有統計學意義（均P＜0．05）。結論閤用GH可改善卵巢反應不良患者IVF-ET的結跼，其機製與提高血清IGF-I濃度、改善卵子質量有關。
목적：관찰중조인생장격소（GH）재행체외수정-배태이식（IVF-ET）초촉배란과정중，대란소반응불량환자치료효과적영향。방법장행IVF/CSI치료적80례란소반응불량환자안수자표법수궤분위량조：가용GH적위관찰조（40례），미용GH적위대조조（40례），관찰기촉성선격소사용총량급천수、획란수급성숙란모세포수、수정솔、란렬솔、획배태수목、우질배태수이급임신솔，병응용ELISA법검측혈청이도소양생장인자I（IGF-I）、이도소양생장인자결합단백3（IGFBP-3）적농도，비교기차이。결과관찰조사용촉성선격소량급천수、획란수급성숙란모세포수、란렬솔、획배태수목、우질배태수균대조조，단차이균무통계학의의（균P＞0.05）；량조혈청IGFBP-3농도차이무통계학의의；량조수정솔、임신솔이급혈청IGF-I농도차이균유통계학의의（균P＜0．05）。결론합용GH가개선란소반응불량환자IVF-ET적결국，기궤제여제고혈청IGF-I농도、개선란자질량유관。
Objective To observe the efficacy of growth hormone ( GH) co-treatment in poor responders undergoing IVF-ET.Methods To analyze all the ovaries low response patients treated by IVF/ICSI,80 cases were ran-domly divided into two groups:40 patients in GH group were given GH along with Gn daily until the HCG administra-tion.40 patients in the control group received the same treatment protocol except the GH co -treatment.The catching spawn number and MⅡova,fertile rate,the number of perfect embryos ,pregnant rate were observed .The serum con-centrations of IGF-I,IGFBP-3 were detected by ELISA and compared between the two groups .Results The number of oocytes retrieved ,number of MII oocytes ,cleavage ,number of embryos available of GH group were increased without statistical significance(all P>0.05 ).The serum IGFBP-3 level of 2 groups had no statistical significance .The fertile rate,pregnant rate ,serum IGF-I level were significantly higher in GH group than those in the control group ( all P<0.05).Conclusion GH co-treatment in poor responders could improve the outcome of IVF-ET,which imply that GH could improve the quality of oocytes and embryos related to the elevated IGF-1 level in serum .
