CAJ | 학술논문

目的：比较阿司匹林与华法林对髋膝关节手术后患者下肢深静脉血栓形成的应用效果。方法选取于本院进行髋膝关节手术的100例患者，将其随机均分为阿司匹林组和华法林组，两组患者在低分子肝素皮下注射基础上分别应用阿司匹林和华法林进行口服治疗，比较两种药物对下肢深静脉血栓的预防效果。结果华法林组下肢深静脉血栓发生率为10.0%，低于阿司匹林组的16.0%，差异有统计学意义(P<0.05)。阿司匹林组发生下肢水肿5例，肺栓塞2例，肝肾功能异常3例，不良反应发生率为20.0%；华法林组发生下肢水肿3例，肺栓塞1例，肝肾功能异常2例，不良反应发生率为12.0%，两组不良反应发生率差异有统计学意义(P<0.05)。结论对于髋膝关节手术患者，与阿司匹林相比，华法林可起到更好的下肢深静脉血栓预防作用，安全性更好，值得临床应用。
목적：비교아사필림여화법림대관슬관절수술후환자하지심정맥혈전형성적응용효과。방법선취우본원진행관슬관절수술적100례환자，장기수궤균분위아사필림조화화법림조，량조환자재저분자간소피하주사기출상분별응용아사필림화화법림진행구복치료，비교량충약물대하지심정맥혈전적예방효과。결과화법림조하지심정맥혈전발생솔위10.0%，저우아사필림조적16.0%，차이유통계학의의(P<0.05)。아사필림조발생하지수종5례，폐전새2례，간신공능이상3례，불량반응발생솔위20.0%；화법림조발생하지수종3례，폐전새1례，간신공능이상2례，불량반응발생솔위12.0%，량조불량반응발생솔차이유통계학의의(P<0.05)。결론대우관슬관절수술환자，여아사필림상비，화법림가기도경호적하지심정맥혈전예방작용，안전성경호，치득림상응용。
Objective To compare the application effect of aspirin and warfarin in prevention of deep vein thrombosis after hip and knee surgery. Methods 100 cases of patients in our hospital for hip and knee surgery were randomly di-vided into aspirin group and warfarin group,aspirin and warfarin was given to two groups respectively on the basis of low molecular weight heparin subcutaneously,the preventive effect of two groups was compared. Results The incidence of deep venous thrombosis in warfarin group was 10.0%,lower than that of the aspirin group (16.0%),the difference was significant (P<0.05).There were 5 cases of lower extremity edema,2 cases of pulmonary embolism,3 cases of liver and kidney dysfunction in aspirin group,the incidence of adverse reactions was 20.0%;there were 3 cases of lower extremity edema,1 case of pulmonary embolism,2 cases of liver and kidney dysfunction in warfarin group,the incidence of adverse reactions was 20.0%;the incidence of adverse reactions of two groups had significant difference (P<0.05). Conclusion For hip knee surgery patients,compared with aspirin,warfarin plays a better role of lower extremity deep vein thrombosis prevention,safety is better,is worthy of application.