中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
22期
45-47
,共3页
新生儿呼吸窘迫综合征%重症%高频振荡通气
新生兒呼吸窘迫綜閤徵%重癥%高頻振盪通氣
신생인호흡군박종합정%중증%고빈진탕통기
Neonatal respiratory distress syndrome%Severe disease%High frequency oscillation ventilation
目的：探讨高频振荡通气(HFOV)治疗重症新生儿呼吸窘迫综合征(RDS)的有效性及安全性。方法选取2008年10月~2013年12月本院新生儿科收治的152例重症新生儿RDS患者为研究对象,入院后按照抽签随机取样法将其分为对照组(n=76)和观察组(n=76)。两组患儿入院后均给予基础治疗,在此基础上对照组患儿给予常频机械通气模式治疗,观察组患儿给予HFOV治疗。比较两组患儿治疗前后的各血气分析指标(pH、PaO2、PaCO2、OI)。比较两组患儿的住院时间、治愈率及并发症发生率。结果治疗前,两组患儿的各血气指标比较,差异均无统计学意义(P>0.05)；治疗后,观察组的pH、PaO2水平显著高于对照组(P<0.05),PaCO2、OI显著低于对照组(P<0.05)。对照组患儿的住院时间为(21.5±4.9)d,观察组为(14.7±3.1)d,观察组的住院时间显著短于对照组(t=7.59,P=0.006)。观察组治愈率为94.7%,显著高于对照组的82.9%(χ2=5.37,P=0.018),并发症发生率为3.9%,显著低于对照组的17.1%(χ2=6.99,P=0.008)。结论 HFOV能明显改善重度新生儿RDS的缺氧状态,改善氧合,缩短住院时间,提高其治愈率,降低并发症发生率,值得临床推广应用。
目的：探討高頻振盪通氣(HFOV)治療重癥新生兒呼吸窘迫綜閤徵(RDS)的有效性及安全性。方法選取2008年10月~2013年12月本院新生兒科收治的152例重癥新生兒RDS患者為研究對象,入院後按照抽籤隨機取樣法將其分為對照組(n=76)和觀察組(n=76)。兩組患兒入院後均給予基礎治療,在此基礎上對照組患兒給予常頻機械通氣模式治療,觀察組患兒給予HFOV治療。比較兩組患兒治療前後的各血氣分析指標(pH、PaO2、PaCO2、OI)。比較兩組患兒的住院時間、治愈率及併髮癥髮生率。結果治療前,兩組患兒的各血氣指標比較,差異均無統計學意義(P>0.05)；治療後,觀察組的pH、PaO2水平顯著高于對照組(P<0.05),PaCO2、OI顯著低于對照組(P<0.05)。對照組患兒的住院時間為(21.5±4.9)d,觀察組為(14.7±3.1)d,觀察組的住院時間顯著短于對照組(t=7.59,P=0.006)。觀察組治愈率為94.7%,顯著高于對照組的82.9%(χ2=5.37,P=0.018),併髮癥髮生率為3.9%,顯著低于對照組的17.1%(χ2=6.99,P=0.008)。結論 HFOV能明顯改善重度新生兒RDS的缺氧狀態,改善氧閤,縮短住院時間,提高其治愈率,降低併髮癥髮生率,值得臨床推廣應用。
목적：탐토고빈진탕통기(HFOV)치료중증신생인호흡군박종합정(RDS)적유효성급안전성。방법선취2008년10월~2013년12월본원신생인과수치적152례중증신생인RDS환자위연구대상,입원후안조추첨수궤취양법장기분위대조조(n=76)화관찰조(n=76)。량조환인입원후균급여기출치료,재차기출상대조조환인급여상빈궤계통기모식치료,관찰조환인급여HFOV치료。비교량조환인치료전후적각혈기분석지표(pH、PaO2、PaCO2、OI)。비교량조환인적주원시간、치유솔급병발증발생솔。결과치료전,량조환인적각혈기지표비교,차이균무통계학의의(P>0.05)；치료후,관찰조적pH、PaO2수평현저고우대조조(P<0.05),PaCO2、OI현저저우대조조(P<0.05)。대조조환인적주원시간위(21.5±4.9)d,관찰조위(14.7±3.1)d,관찰조적주원시간현저단우대조조(t=7.59,P=0.006)。관찰조치유솔위94.7%,현저고우대조조적82.9%(χ2=5.37,P=0.018),병발증발생솔위3.9%,현저저우대조조적17.1%(χ2=6.99,P=0.008)。결론 HFOV능명현개선중도신생인RDS적결양상태,개선양합,축단주원시간,제고기치유솔,강저병발증발생솔,치득림상추엄응용。
Objective To explore the effectiveness and safety of high frequency oscillation ventilation (HFOV) in the treatment of severe neonatal respiratory distress syndrome (RDS). Methods 152 cases of new-born baby with severe neonatal RDS were selected as the research objects from October 2008 to December 2013 hospitalized in Department of neonatologyour of our hospital, according to the random sampling method in the lottery after admission,they were di-vided into the control group (n=76) and the observation group (n=76).The children of two groups were performed foun-dation treatment after admission,on the basis of this,the control group was given conventional mechanical ventilation mode, Children patients of the observation group were given HFOV treatment.Each blood gas index (pH,PaO2,PaCO2,OI) before and after treatment of children of the two groups was compared.Length of hospital stay,cure rate and incidence rate of complication of children in the two groups were compared. Results Before treatment,each blood gas index chil-dren of the two groups were compared,and there was no statistical difference (P>0.05).After treatment,pH,PaO2 level of the observation group were higher than those of the control group (P<0.05),PaCO2,OI were significantly lower than those of the control group(P<0.05).The hospitalization time of children patients in the control group was (21.5±4.9) days, and it was (14.7±3.1) days in the observation group,the hospital stay in the observation group was significantly lower than that in the control group (t=7.59,P=006).Cure rate of the observation group was significantly higher than that of the control group (94.7% vs 82.9%,χ2=5.37,P=0.018),incidence rate of complication in the observation group was signifi-cantly lower than that of control group (3.9% vs 17.1%,χ2=6.99,P=0.008). Conclusion HFOV can obviously improve anaerobic condition of severe neonatal RDS,improve oxygenation,shorten hospitalization time,improve the cure rate and reduce the incidence rate of complication.It is worthy of popularization and application in clinic.
