中国当代医药
中國噹代醫藥
중국당대의약
PERSON
2014年
22期
32-34
,共3页
乙型肝炎%血清免疫标志物%乙型肝炎病毒核酸%乙型肝炎病毒
乙型肝炎%血清免疫標誌物%乙型肝炎病毒覈痠%乙型肝炎病毒
을형간염%혈청면역표지물%을형간염병독핵산%을형간염병독
Hepatitis B%Serum immune marker%Hepatitis B virus nucleic acid%Hepatitis B virus
目的：探讨乙型肝炎血清免疫标志物、乙型肝炎病毒核酸水平变化与HBV的关系及临床意义。方法选取本院2013年2月~2014年2月收治的108例乙型肝炎患者为研究对象,按HBV DNA含量高低分为A(<103拷贝/ml)、B(103~105拷贝/ml)、C(106~108拷贝/ml)3组,分别检测3组的乙型肝炎血清免疫标志物(HBV M)与乙型肝炎病毒核酸(HBV DNA)含量。结果 A组的HBeAg为(3.971±14.47)S/CO,B组为(446.7±785.8)S/CO,两组比较,差异有统计学意义(P<0.05)；A组的抗-HBe、HBeAg、HBsAg与C组比较,差异均有统计学意义(P<0.05)；B组的HBeAg与C组比较,差异有统计学意义(P<0.05)；3组的抗-HBs、抗-HBc比较,差异均无统计学意义(P>0.05)。HBV M阳性标本中抗-HBs、抗-HBc与HBsAg含量与HBV DNA无相关性,抗-HBe与HBV DNA呈负相关,HBeAg与HBV DNA呈正相关。结论定量检测HBV DNA可真实反映HBV的复制情况,对于传染性评价、乙型肝炎诊治及疗效观察均具有指导意义；定量检测HBV M虽在HBV复制程度的判断及传染性评价方面无明显价值,但可为乙型肝炎数据管理奠定基础。
目的：探討乙型肝炎血清免疫標誌物、乙型肝炎病毒覈痠水平變化與HBV的關繫及臨床意義。方法選取本院2013年2月~2014年2月收治的108例乙型肝炎患者為研究對象,按HBV DNA含量高低分為A(<103拷貝/ml)、B(103~105拷貝/ml)、C(106~108拷貝/ml)3組,分彆檢測3組的乙型肝炎血清免疫標誌物(HBV M)與乙型肝炎病毒覈痠(HBV DNA)含量。結果 A組的HBeAg為(3.971±14.47)S/CO,B組為(446.7±785.8)S/CO,兩組比較,差異有統計學意義(P<0.05)；A組的抗-HBe、HBeAg、HBsAg與C組比較,差異均有統計學意義(P<0.05)；B組的HBeAg與C組比較,差異有統計學意義(P<0.05)；3組的抗-HBs、抗-HBc比較,差異均無統計學意義(P>0.05)。HBV M暘性標本中抗-HBs、抗-HBc與HBsAg含量與HBV DNA無相關性,抗-HBe與HBV DNA呈負相關,HBeAg與HBV DNA呈正相關。結論定量檢測HBV DNA可真實反映HBV的複製情況,對于傳染性評價、乙型肝炎診治及療效觀察均具有指導意義；定量檢測HBV M雖在HBV複製程度的判斷及傳染性評價方麵無明顯價值,但可為乙型肝炎數據管理奠定基礎。
목적：탐토을형간염혈청면역표지물、을형간염병독핵산수평변화여HBV적관계급림상의의。방법선취본원2013년2월~2014년2월수치적108례을형간염환자위연구대상,안HBV DNA함량고저분위A(<103고패/ml)、B(103~105고패/ml)、C(106~108고패/ml)3조,분별검측3조적을형간염혈청면역표지물(HBV M)여을형간염병독핵산(HBV DNA)함량。결과 A조적HBeAg위(3.971±14.47)S/CO,B조위(446.7±785.8)S/CO,량조비교,차이유통계학의의(P<0.05)；A조적항-HBe、HBeAg、HBsAg여C조비교,차이균유통계학의의(P<0.05)；B조적HBeAg여C조비교,차이유통계학의의(P<0.05)；3조적항-HBs、항-HBc비교,차이균무통계학의의(P>0.05)。HBV M양성표본중항-HBs、항-HBc여HBsAg함량여HBV DNA무상관성,항-HBe여HBV DNA정부상관,HBeAg여HBV DNA정정상관。결론정량검측HBV DNA가진실반영HBV적복제정황,대우전염성평개、을형간염진치급료효관찰균구유지도의의；정량검측HBV M수재HBV복제정도적판단급전염성평개방면무명현개치,단가위을형간염수거관리전정기출。
Objective To explore the relationship between serum immune marker of hepatitis B,level change of hepati-tis B virus nucleic acid and clinical significance. Methods 108 patients with hepatitis B admitted and treated in our hospital from February 2013 to February 2014 were selected as research objects.The patients were assigned to the three groups according to HBV DNA level:the group A (<103 copy/ml),the group B (103-105 copy /ml) and the group C (106-108 copy/ml).The serum immune marker of hepatitis B (HBV M) and hepatitis B virus nucleic acid (HBV DNA) content were tested for each group. Results HBeAg in the group A and the group B was (3.971±14.47) S/CO and (446.7±785.8) S/CO respectively,and there was a statistical difference in the two groups (P<0.05).The group A and the group C had a statistical difference in anti-HBe,HBeAg and HBsAg level (P<0.05).The group B and the group C had statistical differ-ence in HBeAg level (P<0.05).There was no statistical difference between the three groups in anti-HBs level or anti-HBc level.As for HBV M-positive specimens,anti-HBs level,anti-HBc level and HBsAg level had no correlation with HBV DNA,but anti-HBe level had negative correlation with HBV DNA and HBeAg level had positive correlation with HBV DNA. Conclusion Quantitative detection of HBV DNA level can reflect truly HBV replication,which is of guidence significance for infectivity evaluation and diagnosis and treatment of hepatitis B and efficacy observation.Al-though quantitative detection of HBV M has no significant value for HBV replication determination or infectivity evalu-ation,but it lays the foundation for management of hepatitis B data.
