CAJ | 학술논문

目的：研究和分析胸腺肽α1治疗老年晚期恶性肿瘤的临床效果。方法选取2012年1月~2013年9月在本院接受治疗的60例晚期恶性肿瘤老年患者，随机分为观察组和对照组，每组30例。对照组采用常规治疗，观察组在常规治疗的基础上采用胸腺肽α1治疗，比较两组的治疗效果及不良反应情况。结果观察组的总有效率为60.0%，高于对照组的30.0%，差异有统计学意义(P<0.05)；两组的不良反应发生率比较差异无统计学意义(P>0.05)。治疗前，两组的细胞免疫功能指标比较差异无统计学意义(P>0.05)；治疗后，观察组的CD4/CD8及NK阳性细胞百分率均高于对照组(P<0.05)。结论老年晚期恶性肿瘤患者采用胸腺肽α1治疗的效果确切，不良反应少，值得临床推广应用。
목적：연구화분석흉선태α1치료노년만기악성종류적림상효과。방법선취2012년1월~2013년9월재본원접수치료적60례만기악성종류노년환자，수궤분위관찰조화대조조，매조30례。대조조채용상규치료，관찰조재상규치료적기출상채용흉선태α1치료，비교량조적치료효과급불량반응정황。결과관찰조적총유효솔위60.0%，고우대조조적30.0%，차이유통계학의의(P<0.05)；량조적불량반응발생솔비교차이무통계학의의(P>0.05)。치료전，량조적세포면역공능지표비교차이무통계학의의(P>0.05)；치료후，관찰조적CD4/CD8급NK양성세포백분솔균고우대조조(P<0.05)。결론노년만기악성종류환자채용흉선태α1치료적효과학절，불량반응소，치득림상추엄응용。
Objective To study and analyze the clinical effect of thymosin α1 in the treatment of elderly patients with advanced malignant tumor. Methods Sixty cases of elderly patients with advanced malignant tumor accepted treatment in our hospital from January 2012 to September 2013 were selected and evenly divided into observation group and control group in random.In the control group,patients were provided with regular treatment,while in the observation group,on the basis of the control group,thymosin α1 was added.The therapeutic effect and adverse reaction in the both groups was compared respectively. Results The total effective rate in the observation group was 60.0%,higher than that in the control group(30.0%),with a statistical difference(P<0.05).There was no statistical difference in incidence rate of adverse reaction between two groups (P>0.05).Before treatment,cellular immune function in both groups was compared, with no statistical difference (P>0.05).After therapy,CD4/CD8 and the percentage of natural killer positive cell in the observation group was higher than that in the control group respectively (P<0.05). Conclusion Application of thymosinα1 in the treatment of advanced malignant tumors in the old can obtain a definite effect with few adverse reaction,which is worthy of expansion and application in clinic.