CAJ | 학술논문

目的：探讨妊娠糖尿病合并胆石症与胰岛素抵抗之间的相互关系。方法采用病例对照法,分别测定40例单纯妊娠糖尿病(A组)及40例妊娠糖尿病合并胆石症(B组)患者的空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),并计算胰岛素抵抗指数(HOMA-IR)和胰岛素敏感指数(ISI),观察各指标的变化及其相互关系。结果与A组比较,B组患者的FPG、FINS、TG、TC、LDL-C明显升高,ISI显著下降,HDL-C无显著性变化,存在更明显的胰岛素抵抗。 ISI与TG、TC、LDL-C呈负相关,与HDL-C呈正相关,多元回归分析显示胆石症与ISI呈负相关,与HOMA-IR呈正相关。结论胰岛素抵抗可能是导致妊娠糖尿病形成胆石症的危险因素,积极改善妊娠糖尿病胰岛素抵抗的相关因素,可能成为预防妊娠糖尿病合并胆石症的一种方案。
목적：탐토임신당뇨병합병담석증여이도소저항지간적상호관계。방법채용병례대조법,분별측정40례단순임신당뇨병(A조)급40례임신당뇨병합병담석증(B조)환자적공복혈당(FPG)、공복이도소(FINS)、총담고순(TC)、삼선감유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C),병계산이도소저항지수(HOMA-IR)화이도소민감지수(ISI),관찰각지표적변화급기상호관계。결과여A조비교,B조환자적FPG、FINS、TG、TC、LDL-C명현승고,ISI현저하강,HDL-C무현저성변화,존재경명현적이도소저항。 ISI여TG、TC、LDL-C정부상관,여HDL-C정정상관,다원회귀분석현시담석증여ISI정부상관,여HOMA-IR정정상관。결론이도소저항가능시도치임신당뇨병형성담석증적위험인소,적겁개선임신당뇨병이도소저항적상관인소,가능성위예방임신당뇨병합병담석증적일충방안。
Objective To study the correlation between the insulin resistancce and cholelithiasis in patients with ges-tational diabetes mellitus. Methods A case-match study was carried out,the fasting blood glucose (FPG),fasting insulin (FINS),total cholesterol (TC),higher triglyceride(TG),high density lipoprotein cholesterol (HDL-C),low density lipoprotein cholesterol (LDL-C) were measured in 40 gestational diabetes mellitus with cholelithiasis (group A) and 40 without cholelithiasis (group B),retrospectively.Insulin resistance (HOMA-IR) and insulin sensitivity index(ISI) were calculated. The changes of the indicators were observed and their correlation were analyzed. Results Compared with group A,the FBG,FINS,TG,TC,LDL-C were significantly increased and ISI was decreased,HDL-C was no significantly changed and there was significantly insulin resistance in group B.ISI was negatively correlated with TG,TC and LDL-C,and positive-ly with HDL-C.Multiple regression analysis showed that there was negative correlation between cholelithiasis and ISI, and positively with HOMA-IR. Conclusion Insulin resistance might be a risk factor for gestational diabetes mellitus with cholelith.Actively improve the related factors of gestational diabetes mellitus insulin resistance,can be prevent ges-tational diabetes mellitus with cholelith.