CAJ | 학술논문

目的：对比分析血清学无创肝纤维化检测与肝脏穿刺病理检测在慢性乙型肝炎临床诊断中的应用及各自具有的优势和劣势。方法选取2012年4月~2013年3月期间我院门诊收治的97例慢性乙型肝炎患者作为本研究的观察对象,分别对患者进行血清学无创肝纤维化检测与肝脏穿刺病理检测,对比两种检测结果。结果所有患者的血清学无创肝纤维化检测指标(PⅢP、Ⅳ-C、HA、LN)与病理分期呈良好的正相关。相关系数显示HA >LN>PⅢP>Ⅳ-C,提示随着肝纤维化程度加重,肝纤维化检测指标有逐渐升高的趋向,各项指标差异均有统计学意义(P<0.05)。结论肝脏穿刺病理检测是慢性乙型肝炎患者诊断的“金标准”,但对患者损伤较大。血清学无创肝纤维化检测具有较高的诊断价值,能够减少穿刺活检的数量。
목적：대비분석혈청학무창간섬유화검측여간장천자병리검측재만성을형간염림상진단중적응용급각자구유적우세화열세。방법선취2012년4월~2013년3월기간아원문진수치적97례만성을형간염환자작위본연구적관찰대상,분별대환자진행혈청학무창간섬유화검측여간장천자병리검측,대비량충검측결과。결과소유환자적혈청학무창간섬유화검측지표(PⅢP、Ⅳ-C、HA、LN)여병리분기정량호적정상관。상관계수현시HA >LN>PⅢP>Ⅳ-C,제시수착간섬유화정도가중,간섬유화검측지표유축점승고적추향,각항지표차이균유통계학의의(P<0.05)。결론간장천자병리검측시만성을형간염환자진단적“금표준”,단대환자손상교대。혈청학무창간섬유화검측구유교고적진단개치,능구감소천자활검적수량。
Objective To compare the serological non-invasive liver fibrosis tests and pathological examination in the clinical diagnosis of chronic hepatitis B. Methods Selected 97 patients with chronic hepatitis B in our hospital as the research object and tested non-invasive liver fibrosis tests and liver biopsy pathological examination.Compare the test results of two kinds. Results The serum noninvasive hepatic fibrosis index(PⅢP,Ⅳ-C,HA,LN)showed good positive correlation with pathological stage. The correlation coefficient suggested that with the aggravation of hepatic fibrosis,liv-er fibrosis indexes tended to rise gradually,and the indicators differences were statistically significant (P<0.05). Con-clusion Liver biopsy in patients with chronic hepatitis B diagnosis detection is the "gold standard" with greater injury. Serological non-invasive liver fibrosis tests has high diagnostic value,can reduce the number of puncture biopsy.