CAJ | 학술논문

目的：检查胃癌组织及癌旁组织中HCCR、pERK及pELK1的表达，探讨之间的相关性。方法通过免疫组化方法检测60例胃癌及癌旁组织中HCCR、pERK及pELK1的表达情况。结果 HCCR、pERK及pELK1在胃癌组织中的阳性表达率分别为75.0%(45/60)、73.3%(44/60)及71.7%(43/60)，均高于其在癌旁组织中的表达，差异均有统计学意义(P<0.05)。结论 HCCR、pERK及 pELK1三者之间具有一定的协调表达率，在肿瘤组织中表达明显增高，可用来作为胃癌临床免疫组化的辅助指标。
목적：검사위암조직급암방조직중HCCR、pERK급pELK1적표체，탐토지간적상관성。방법통과면역조화방법검측60례위암급암방조직중HCCR、pERK급pELK1적표체정황。결과 HCCR、pERK급pELK1재위암조직중적양성표체솔분별위75.0%(45/60)、73.3%(44/60)급71.7%(43/60)，균고우기재암방조직중적표체，차이균유통계학의의(P<0.05)。결론 HCCR、pERK급 pELK1삼자지간구유일정적협조표체솔，재종류조직중표체명현증고，가용래작위위암림상면역조화적보조지표。
Objective To explore the expression of HCCR, pERK and pELK1 in gastric cancer tissue and para-carci-noma tissue, and to explove its correlations. Methods In 60 human gastric cancers and their corresponding paraneo-plastic tissuses,the expression of HCCR, pERK and pELK1 were detected by immunohistochemistry. Results The ex-pression of HCCR was 75.0%(45/60), pERK, and pELK1 were 73.3%(44/60) and 71.7%(43/60), respectively, and the expression of proteins in gastric tumor were higher than that in paraneoplastic tissues (P<0.05). Conclusion The HCCR, pERK and pELK1 are higher expressed in tumor tissues, availably as a auxiliary index for clinical immunohis-tochemistry in gastric cancer.