CAJ | 학술논문

目的：观察甘露醇联合小剂量地塞米松治疗早期重症手足口病临床效果。方法选取330例早期重症手足口病患儿为观察组，及类似的早期重症手足口病患儿330例为对照组。对照组给予利巴韦林、喜炎平加入0.9%氯化钠注射液静脉滴注，及常规和对症支持治疗。观察组在对照组的治疗基础上给予甘露醇联合小剂量地塞米松治疗。观察比较两组患儿发展为危重症的例数、发热和肢体抖动或惊跳消失时间、脑膜刺激征消失时间。结果观察组患儿发展为危重症的例数明显少于对照组（P<0.01）；观察组发热消退时间、惊跳或肢体抖动消失时间、脑膜刺激征消失时间均明显少于对照组（P<0.01）。结论甘露醇联合小剂量地塞米松治疗早期重症手足口病，能有效防止患者进展为危重症，保护脑功能。
목적：관찰감로순연합소제량지새미송치료조기중증수족구병림상효과。방법선취330례조기중증수족구병환인위관찰조，급유사적조기중증수족구병환인330례위대조조。대조조급여리파위림、희염평가입0.9%록화납주사액정맥적주，급상규화대증지지치료。관찰조재대조조적치료기출상급여감로순연합소제량지새미송치료。관찰비교량조환인발전위위중증적례수、발열화지체두동혹량도소실시간、뇌막자격정소실시간。결과관찰조환인발전위위중증적례수명현소우대조조（P<0.01）；관찰조발열소퇴시간、량도혹지체두동소실시간、뇌막자격정소실시간균명현소우대조조（P<0.01）。결론감로순연합소제량지새미송치료조기중증수족구병，능유효방지환자진전위위중증，보호뇌공능。
Objective To observe the effects on early severe HFMD treated by mannitol combined with low dose dexamethason. Methods 330 children with early severe HFMD were chosen to be observation group. 330 children with similar cases before were chosen to be control group. Control group were treated by ribavirin, xiyanping injection intravenous drip. The children were treated by conventional and symptomatic treatment. Observation group were treated by mannitol combined with low dose dexamethason based on the therapy of control group. The cases of critical cases, fever and limb jitter or startle disappear time, meningeal irritation sign in two groups were compared. Results Observation group was better than control group in critical cases(P<0.01). In observation group, the time of bring down a fever, limb jitter or startle disappear time and disappear time of meningeal irritation sign were signiifcantly lower than control group’s (P<0.01). Conclusions Mannitol combined with low dose dexamethason treated on early severe HFMD could prevent the patients become the critical cases.