CAJ | 학술논문

[目的]探讨冠心病病人幽门螺杆菌(HP)感染的发生状况及其与血脂代谢的关系。[方法]选取知情同意的冠心病住院病人159例,根据14C尿素呼气试验结果将病人分为HP感染组和HP非感染组,同时测定其血脂水平,分析HP感染冠心病病人血脂水平与冠状动脉病变严重程度的相关性。[结果]冠心病病人HP感染组血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDLC)水平高于HP非感染组,差异均具有统计学意义(P<0.05或P<0.01)；随着冠心病病人体内HP感染程度的加重,其TC、TG、LDLC水平亦相应增高,HP不同感染程度病人血清TC、TG、LDLC水平差异均具有统计学意义(P<0.05或P<0.01),血清高密度脂蛋白胆固醇(HDLC)水平随着冠心病病人体内HP感染程度的加重而降低；HP感染冠心病病人血清TC、TG、LDLC水平随着冠状动脉病变严重程度增加而呈递增趋势,血清HDLC水平随着冠状动脉病变严重程度增加而呈下降趋势。[结论]HP感染可能通过影响机体脂质代谢,促进动脉粥样硬化的形成,是冠状动脉粥样硬化病变的重要危险因素,进而诱发冠心病。
[목적]탐토관심병병인유문라간균(HP)감염적발생상황급기여혈지대사적관계。[방법]선취지정동의적관심병주원병인159례,근거14C뇨소호기시험결과장병인분위HP감염조화HP비감염조,동시측정기혈지수평,분석HP감염관심병병인혈지수평여관상동맥병변엄중정도적상관성。[결과]관심병병인HP감염조혈청총담고순(TC)、삼선감유(TG)、저밀도지단백담고순(LDLC)수평고우HP비감염조,차이균구유통계학의의(P<0.05혹P<0.01)；수착관심병병인체내HP감염정도적가중,기TC、TG、LDLC수평역상응증고,HP불동감염정도병인혈청TC、TG、LDLC수평차이균구유통계학의의(P<0.05혹P<0.01),혈청고밀도지단백담고순(HDLC)수평수착관심병병인체내HP감염정도적가중이강저；HP감염관심병병인혈청TC、TG、LDLC수평수착관상동맥병변엄중정도증가이정체증추세,혈청HDLC수평수착관상동맥병변엄중정도증가이정하강추세。[결론]HP감염가능통과영향궤체지질대사,촉진동맥죽양경화적형성,시관상동맥죽양경화병변적중요위험인소,진이유발관심병。
Obj ective:To probe into the occurrence of helicobacter pylori (HP)infection in patients with coronary heart disease and its relation-ship with blood lipid metabolism.Methods:A total of 1 5 9 cases of in-formed consent of inpatients with coronary heart disease were selected and divided into HP infection group and HP non infection group based on the 14 C urea breath test results.The blood lipid level was measured, and the correlation was analyzed between the blood lipid level of CHD patients with helicobacter pylori (HP)infection and severity degree of coronary artery lesions.Results:The total serum cholesterol (TC),tri-glyceride(TG)and low density lipoprotein cholesterol(LDL C)levels in HP infection group were higher than that of HP non infection group,and the differences were statistically significant(P<0.05 or P<0.01);with the extent of HP infection aggravating in coronary artery disease patients,the TC,TG,LDL C levels also increased accordingly. There was statistically significant difference in serum TC,TG,LDL C level among patients with different degrees of HP infection(P<0.05 or P<0.01),serum high density lipoprotein cholesterol(HDL C)level decreased with the HP infection aggravated in CHD patients;the serum TC,TG,LDL C levels showed an increasing trend with increasing of severity of coronary artery lesions in HP infection patients.Serum HDL C level de-creased with increasing of severity of coronary artery lesions.Conclusion:HP infection may promote the formation of atherosclerosis through affecting the body lipid metabolism.It is the important risk factor of coronary atheroscle-rotic lesions,and then to induce coronary heart disease.