CAJ | 학술논문

目的：探讨检测乳腺癌特异基因1（ breast cancer specific gene l ，BCSG1）在三阴性乳腺癌与非三阴性乳腺癌中的表达。方法回顾性分析170例女性乳腺疾病患者资料，其中160例乳腺癌、10例良性乳腺病。采用免疫组织化学S-P法（ Immunohistochemistry ）检测所有标本的BCSG1表达情况。结果非三阴性乳腺癌BCSG1表达率41．0％低于三阴性乳腺癌的57．5％（χ2＝4．2，P＝0．04）。结论 BCSG1在三阴性乳腺癌中表达率高，是三阴性乳腺癌的独特性基因，可作为研究三阴性乳腺癌治疗的新靶点。
목적：탐토검측유선암특이기인1（ breast cancer specific gene l ，BCSG1）재삼음성유선암여비삼음성유선암중적표체。방법회고성분석170례녀성유선질병환자자료，기중160례유선암、10례량성유선병。채용면역조직화학S-P법（ Immunohistochemistry ）검측소유표본적BCSG1표체정황。결과비삼음성유선암BCSG1표체솔41．0％저우삼음성유선암적57．5％（χ2＝4．2，P＝0．04）。결론 BCSG1재삼음성유선암중표체솔고，시삼음성유선암적독특성기인，가작위연구삼음성유선암치료적신파점。
Objective To explore the expression of BCSG 1 in the triple negative breast cancer and the non-triple-negative breast cancer and its significance .Methods The clinical data from 170 patients were retrospectively analyzed,which including 160 breast cancer and 10 benign breast disease .We checked the expression of BCSG 1 in the specimens by the immunohistochemistry to analysis the similarities and differences the BCSG 1 between the triple negative breast cancer and the non-triple negative breast cancer .Results The expression rate of the BCSG 1 was 41.0%in the non-triple negative breast cancer , which was lower than 57.5% in the triple negative breast cancer (χ2 =4.2,P=0.04).Conclusion The expression rate of the BCSG1 in the triple-negative breast cancer is higher than that in the non-triple-negative breast cancer.and it was statistically significant (P<0.05),so the expression of BCSG1 in triple negative breast cancer is unique .It prompt that BCSG1 can be a new treatment target in the triple negative breast cancer .