国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2013年
4期
491-493
,共3页
强化降脂%急性冠脉综合征%经皮冠状动脉介入治疗
彊化降脂%急性冠脈綜閤徵%經皮冠狀動脈介入治療
강화강지%급성관맥종합정%경피관상동맥개입치료
Intensive lipid-lowering%Acute coronary syndrome (ACS)%Percutaneous coronary intervention (PCI)
目的 探讨强化降脂治疗对急性冠脉综合征经皮冠状动脉介入治疗效果的影响.方法 选取2011年1月至2012年8月我院收治的急性冠脉综合征患者160例,随机分为实验组和对照组,PCI术前1周,实验组采用80 mg辛伐他汀治疗,对照组采用20 mg辛伐他汀治疗.结果 支架置入后实验组中TIMI血流0、1级例数均明显少于对照组,而TIMI血流3级例数均明显多于对照组(P＜0.05)；两组患者的TMPG-3、无复流情况差异有显著性(P＜0.05).PCI后24h实验组患者的血清hs-CRP、ICAM和P选择素水平明显低于对照组(P＜0.05).结论 急性冠脉综合征患者于PCI术前接受强化他汀治疗可更有效地改善其心肌灌注,减轻心肌损伤.
目的 探討彊化降脂治療對急性冠脈綜閤徵經皮冠狀動脈介入治療效果的影響.方法 選取2011年1月至2012年8月我院收治的急性冠脈綜閤徵患者160例,隨機分為實驗組和對照組,PCI術前1週,實驗組採用80 mg辛伐他汀治療,對照組採用20 mg辛伐他汀治療.結果 支架置入後實驗組中TIMI血流0、1級例數均明顯少于對照組,而TIMI血流3級例數均明顯多于對照組(P＜0.05)；兩組患者的TMPG-3、無複流情況差異有顯著性(P＜0.05).PCI後24h實驗組患者的血清hs-CRP、ICAM和P選擇素水平明顯低于對照組(P＜0.05).結論 急性冠脈綜閤徵患者于PCI術前接受彊化他汀治療可更有效地改善其心肌灌註,減輕心肌損傷.
목적 탐토강화강지치료대급성관맥종합정경피관상동맥개입치료효과적영향.방법 선취2011년1월지2012년8월아원수치적급성관맥종합정환자160례,수궤분위실험조화대조조,PCI술전1주,실험조채용80 mg신벌타정치료,대조조채용20 mg신벌타정치료.결과 지가치입후실험조중TIMI혈류0、1급례수균명현소우대조조,이TIMI혈류3급례수균명현다우대조조(P＜0.05)；량조환자적TMPG-3、무복류정황차이유현저성(P＜0.05).PCI후24h실험조환자적혈청hs-CRP、ICAM화P선택소수평명현저우대조조(P＜0.05).결론 급성관맥종합정환자우PCI술전접수강화타정치료가경유효지개선기심기관주,감경심기손상.
Objective To discuss the effect of intensive lipid-lowering on acute coronary syndrome (ACS) during percutaneous coronary intervention (PCI).Methods 160 patients of ACS from Jan 2011 to Aug 2012 were divided into 2 groups.The experimental group used 80 mg Simvastatin while the control group used 20 mg Simvastatin 1 week before PCI.Results The cases of TIMI 0 and 1 grade of experimental group were lower than those of control group while the cases of TIMI 3 grade were more than those in control group (P＜0.05).The diverse of state of TMPG-3 and no-reflow of two groups had significance (P＜0.05).The levels of hs-CRP,ICAM and P-slectin of experiment group were lower than those of control group 24 h after PCI.Conclusion Intensive statin therapy before PCI can effectively improve myocardial perfusion and decrease myocardial damage for patients of ACS.
