中国医药科学
中國醫藥科學
중국의약과학
CHINA MEDICINE AND PHARMACY
2014年
15期
161-164
,共4页
内异症%腹腔镜%促性腺激素释放激素激动剂
內異癥%腹腔鏡%促性腺激素釋放激素激動劑
내이증%복강경%촉성선격소석방격소격동제
Endometriosis%Laparoscopy%Gonadotrophin-releasing hormone agonists(GnRH-a)
目的：探讨促性腺激素释放激素激动剂（GnRH-a）在腹腔镜治疗内异症中的效果。方法以我院2011年7月～2013年7月间收治的100例内异症患者为研究对象，随机分为观察组与对照组，所有患者均使用腹腔镜对内异症进行手术，观察组患者在此基础上增加使用GnRH-a，比较两组患者手术效果、术后激素水平、康复期临床症状及复发率之间的差异。结果观察组手术时间、术中出血量、术后通气时间、下床活动时间分别为（68.21±12.94）min、（112.73±35.94）mL、（28.93±4.82）h和（25.49±4.01）h，对照组分别为（82.67±10.27）min、（168.39±41.82）mL、（34.39±3.08）h和（32.10±4.20）h，观察组患者手术效果优于对照组。观察组促卵泡激素、雌二醇和骨钙素水平分别为（3.28±1.93）U/L、（57.48±15.02）pmol/L和（17.59±5.40）μg/L，对照组为（5.03±1.48）U/L、（88.39±13.84）pmol/L和（18.21±6.02）μg/L，观察组术后激素水平低于对照组，其康复期症状得分亦总体低于对照组。观察组患者复发或无效率为6.00%，对照组为22.00%，观察组患者术后复发及无效率低于对照组，上述比较差异皆具有统计学意义（P＜0.05）。结论GnRH-a在腹腔镜治疗内异症中可以起到积极效果，其可提高手术效果、抑制患者激素水平、改善患者临床症状、降低复发率。
目的：探討促性腺激素釋放激素激動劑（GnRH-a）在腹腔鏡治療內異癥中的效果。方法以我院2011年7月～2013年7月間收治的100例內異癥患者為研究對象，隨機分為觀察組與對照組，所有患者均使用腹腔鏡對內異癥進行手術，觀察組患者在此基礎上增加使用GnRH-a，比較兩組患者手術效果、術後激素水平、康複期臨床癥狀及複髮率之間的差異。結果觀察組手術時間、術中齣血量、術後通氣時間、下床活動時間分彆為（68.21±12.94）min、（112.73±35.94）mL、（28.93±4.82）h和（25.49±4.01）h，對照組分彆為（82.67±10.27）min、（168.39±41.82）mL、（34.39±3.08）h和（32.10±4.20）h，觀察組患者手術效果優于對照組。觀察組促卵泡激素、雌二醇和骨鈣素水平分彆為（3.28±1.93）U/L、（57.48±15.02）pmol/L和（17.59±5.40）μg/L，對照組為（5.03±1.48）U/L、（88.39±13.84）pmol/L和（18.21±6.02）μg/L，觀察組術後激素水平低于對照組，其康複期癥狀得分亦總體低于對照組。觀察組患者複髮或無效率為6.00%，對照組為22.00%，觀察組患者術後複髮及無效率低于對照組，上述比較差異皆具有統計學意義（P＜0.05）。結論GnRH-a在腹腔鏡治療內異癥中可以起到積極效果，其可提高手術效果、抑製患者激素水平、改善患者臨床癥狀、降低複髮率。
목적：탐토촉성선격소석방격소격동제（GnRH-a）재복강경치료내이증중적효과。방법이아원2011년7월～2013년7월간수치적100례내이증환자위연구대상，수궤분위관찰조여대조조，소유환자균사용복강경대내이증진행수술，관찰조환자재차기출상증가사용GnRH-a，비교량조환자수술효과、술후격소수평、강복기림상증상급복발솔지간적차이。결과관찰조수술시간、술중출혈량、술후통기시간、하상활동시간분별위（68.21±12.94）min、（112.73±35.94）mL、（28.93±4.82）h화（25.49±4.01）h，대조조분별위（82.67±10.27）min、（168.39±41.82）mL、（34.39±3.08）h화（32.10±4.20）h，관찰조환자수술효과우우대조조。관찰조촉란포격소、자이순화골개소수평분별위（3.28±1.93）U/L、（57.48±15.02）pmol/L화（17.59±5.40）μg/L，대조조위（5.03±1.48）U/L、（88.39±13.84）pmol/L화（18.21±6.02）μg/L，관찰조술후격소수평저우대조조，기강복기증상득분역총체저우대조조。관찰조환자복발혹무효솔위6.00%，대조조위22.00%，관찰조환자술후복발급무효솔저우대조조，상술비교차이개구유통계학의의（P＜0.05）。결론GnRH-a재복강경치료내이증중가이기도적겁효과，기가제고수술효과、억제환자격소수평、개선환자림상증상、강저복발솔。
Objective To explore the effect of gonadotrophin-releasing hormone agonists(GnRH-a) in the laparoscopic treatment of endometriosis. Methods 100 patients with endometriosis who were admitted in our hospital from July 2011 to July 2013 were selected as research subjects and randomly allocated to an observation group and a control group. All patients received laparoscopy for treating endometriosis, and the observation group further received GnRH-a. Operative effect, postoperative hormone levels, clinical symptoms during convalescence and relapse rate were compared between the two groups. Results Surgery time, amount of bleeding during surgery, time of postoperative passage of gas and exercise time were(68.21±12.94) min,(112.73±35.94) mL,(28.93±4.82) h and (25.49±4.01) h respectively in the observation group, and(82.67±10.27) min,(168.39±41.82) mL,(34.39±3.08) h and (32.10±4.20) h respectively in the control group, and the operative effect in the observation group was better than that in the control group. Levels of follicle-stimulating hormone, estradiol and osteocalcin were(3.28±1.93) U/L,(57.48±15.02) pmol/L and(17.59±5.40) μg/L respectively in the observation group, and(5.03±1.48) U/L, (88.39±13.84) pmol/L and(18.21±6.02)μg/L respectively in the control group. The postoperative hormone levels in the observation group were lower than those in the control group, and the scores of symptoms during convalescence were lower than those in the control group. Relapse rate or ineffective rate was 6.00% in the observation group and 22.00% in the control group, and the relapse rate or ineffective rate in the observation group was lower than that in the control group. The differences above were all statistically significant(P < 0.05). Conclusion GnRH-a in the laparoscopic treatment of endometriosis has an active effect, which improves operative effect, inhibits patients’ hormone levels, alleviate patients’clinical symptoms and reduces relapse rate.
