广西师范大学学报（自然科学版）
廣西師範大學學報（自然科學版）
엄서사범대학학보（자연과학판）
JOURNAL OF GUANGXI NORMAL UNIVERSITY(NATURAL SCIENCE EDITION)
2014年
3期
125-132
,共8页
运动强度%动脉粥样硬化%氧化修饰%保护
運動彊度%動脈粥樣硬化%氧化脩飾%保護
운동강도%동맥죽양경화%양화수식%보호
exercise intensity%atherosclerosis%oxidative modification%protection
为比较并探讨不同强度耐力运动对较短周期高脂饮食大鼠动脉粥样硬化(AS)形成的干预作用,将成年雄性 SD 大鼠50只,随机分为正常对照组(N 组)与高脂饲料组(H 组)、大强度运动组(Hh 组)、中等强度运动组(Hm 组)、小强度运动组(Hl 组)：观察各组大鼠胸主动脉有无 AS 病变,分析 AS 发病率与 AS 斑块面积；检测血清 TC、TG、LDL-C、HDL-C 及 SOD、MDA 与 ox-LDL 指标,结果发现：6周高脂饮食喂养引起大鼠血清 TC、LDL-C、MDA 及 ox-LDL 水平显著升高,AS 发病率显著升高、发病程度为轻度；与 H 组相比,Hh组、Hm 组及 Hl 组 TC、LDL-C 水平显著下降,此外 Hl 组 HDL-C 浓度显著升高；Hh 组、Hm 组、Hl 组 MDA含量均显著低于 H 组,但 Hl 组 SOD 活性无显著提高；Hl 组 ox-LDL 及 AS 病变面积百分比显著低于 H 组。可见 6周高脂饮食引起大鼠血脂异常、自由基代谢水平显著升高,从而引起 LDL 氧化修饰反应增加,诱发轻度 AS 病变；小强度运动似乎调血脂作用最佳,从而使控制 LDL 氧化修饰反应的效应放大而加强了抗 AS 形成作用。
為比較併探討不同彊度耐力運動對較短週期高脂飲食大鼠動脈粥樣硬化(AS)形成的榦預作用,將成年雄性 SD 大鼠50隻,隨機分為正常對照組(N 組)與高脂飼料組(H 組)、大彊度運動組(Hh 組)、中等彊度運動組(Hm 組)、小彊度運動組(Hl 組)：觀察各組大鼠胸主動脈有無 AS 病變,分析 AS 髮病率與 AS 斑塊麵積；檢測血清 TC、TG、LDL-C、HDL-C 及 SOD、MDA 與 ox-LDL 指標,結果髮現：6週高脂飲食餵養引起大鼠血清 TC、LDL-C、MDA 及 ox-LDL 水平顯著升高,AS 髮病率顯著升高、髮病程度為輕度；與 H 組相比,Hh組、Hm 組及 Hl 組 TC、LDL-C 水平顯著下降,此外 Hl 組 HDL-C 濃度顯著升高；Hh 組、Hm 組、Hl 組 MDA含量均顯著低于 H 組,但 Hl 組 SOD 活性無顯著提高；Hl 組 ox-LDL 及 AS 病變麵積百分比顯著低于 H 組。可見 6週高脂飲食引起大鼠血脂異常、自由基代謝水平顯著升高,從而引起 LDL 氧化脩飾反應增加,誘髮輕度 AS 病變；小彊度運動似乎調血脂作用最佳,從而使控製 LDL 氧化脩飾反應的效應放大而加彊瞭抗 AS 形成作用。
위비교병탐토불동강도내력운동대교단주기고지음식대서동맥죽양경화(AS)형성적간예작용,장성년웅성 SD 대서50지,수궤분위정상대조조(N 조)여고지사료조(H 조)、대강도운동조(Hh 조)、중등강도운동조(Hm 조)、소강도운동조(Hl 조)：관찰각조대서흉주동맥유무 AS 병변,분석 AS 발병솔여 AS 반괴면적；검측혈청 TC、TG、LDL-C、HDL-C 급 SOD、MDA 여 ox-LDL 지표,결과발현：6주고지음식위양인기대서혈청 TC、LDL-C、MDA 급 ox-LDL 수평현저승고,AS 발병솔현저승고、발병정도위경도；여 H 조상비,Hh조、Hm 조급 Hl 조 TC、LDL-C 수평현저하강,차외 Hl 조 HDL-C 농도현저승고；Hh 조、Hm 조、Hl 조 MDA함량균현저저우 H 조,단 Hl 조 SOD 활성무현저제고；Hl 조 ox-LDL 급 AS 병변면적백분비현저저우 H 조。가견 6주고지음식인기대서혈지이상、자유기대사수평현저승고,종이인기 LDL 양화수식반응증가,유발경도 AS 병변；소강도운동사호조혈지작용최가,종이사공제 LDL 양화수식반응적효응방대이가강료항 AS 형성작용。
To explore the effects and its mechanism of different intensity exercise on atherosclerosis (AS)formation in Rats fed with high fat diet for short cycle,50 rown male SD rats were randomly divid-ed into normal control group (group N),high fat diet group (group H),high intensity exercise group (group Hh),moderate intensity exercise group (group Hm),and low intensity exercise group (group Hl).Observe whether the thoracic aorta AS lesions existed in rats,analyze AS incidence and AS plaque area,and detect serum TC,TG,LDL-C,HDL-C and SOD,MDA and ox-LDL indexs.The results show that serum TC,LDL-C,MDA and ox-LDL levels increased significantly in rats fed with high fat diet for six weeks,and AS incidence increased significantly,comparing with group H.TC and LDL-C levels de-creased significantly in group Hh,group Hm and group Hl,HDL-C level increased significantly in group Hl.In Group Hh,group Hm,group Hl,MDA levels were significantly lower than those of group H,but SOD activity was not increased apparently in group Hl.In group Hl,ox-LDL level and AS plaque area percentage were significantly lower than that of group H.It draw a conclusion that high fat diet for 6 weeks causing dyslipidemia,free radical metabolism increased,and the increase in LDL oxidation modifi-cation led to mild AS.To regulating blood fat,effect of low intensity exercise is the best,so low intensi-ty exercise can control the reaction of LDL oxidative modification and strengthen the role of anti AS for-mation.
