中华行为医学与脑科学杂志
中華行為醫學與腦科學雜誌
중화행위의학여뇌과학잡지
CHINESE JOURNAL OF BEHAVIORAL MEDICINE AND BRAIN SCIENCE
2013年
7期
616-618
,共3页
艾司西酞普兰%围产期%心理治疗%产后抑郁
艾司西酞普蘭%圍產期%心理治療%產後抑鬱
애사서태보란%위산기%심리치료%산후억욱
Escitalopram%Peri-parturition period%Psychotherapy%Postpartum depression
目的 探讨艾司西酞普兰治疗联合围产期心理干预对产后抑郁的临床效果.方法 对2012年7 ～ 12月就诊的493名孕产妇,实施围产期心理干预,其中34例产后抑郁患者作为研究组给予艾司西酞普兰治疗和系统化心理治疗；对2012年1～6月未实施围产期心理干预的367名孕产妇中32例产后抑郁患者作为对照组给予艾司西酞普兰治疗和支持性心理治疗,艾司西酞普兰剂量为10 mg/日,观察8周.治疗前及治疗后1,2,4,8周末分别用汉密顿抑郁量表(HAMD)和临床疗效总评量表(CGI)进行评定,然后两组资料进行比较.结果 产后抑郁发生率研究组为7.7％,显著低于对照组(11.7％,x2 =3.96,P＜0.05).治疗后第1、2、4、8周各时点,研究组的HAMD总分为(16.6±3.8)分、(12.4±3.2)分、(8.8±3.4)分、(6.7±2.3)分,显著低于对照组[(19.4 ±3.4)分、(14.7±3.0)分、(11.2±2.8)分、(8.2±2.7)分,t=2.43～3.15,P＜0.05或P＜0.01).治疗后各时点的CGI-SI评分研究组均显著低于对照组(P＜0.05或P＜0.01).不良反应两组之间差异无统计学意义(P＞0.05).结论 在围产期实施心理干预、在产后抑郁患病期给予艾司西酞普兰联合系统化心理治疗对预防产后抑郁和促进产后抑郁的康复效果更好.
目的 探討艾司西酞普蘭治療聯閤圍產期心理榦預對產後抑鬱的臨床效果.方法 對2012年7 ～ 12月就診的493名孕產婦,實施圍產期心理榦預,其中34例產後抑鬱患者作為研究組給予艾司西酞普蘭治療和繫統化心理治療；對2012年1～6月未實施圍產期心理榦預的367名孕產婦中32例產後抑鬱患者作為對照組給予艾司西酞普蘭治療和支持性心理治療,艾司西酞普蘭劑量為10 mg/日,觀察8週.治療前及治療後1,2,4,8週末分彆用漢密頓抑鬱量錶(HAMD)和臨床療效總評量錶(CGI)進行評定,然後兩組資料進行比較.結果 產後抑鬱髮生率研究組為7.7％,顯著低于對照組(11.7％,x2 =3.96,P＜0.05).治療後第1、2、4、8週各時點,研究組的HAMD總分為(16.6±3.8)分、(12.4±3.2)分、(8.8±3.4)分、(6.7±2.3)分,顯著低于對照組[(19.4 ±3.4)分、(14.7±3.0)分、(11.2±2.8)分、(8.2±2.7)分,t=2.43～3.15,P＜0.05或P＜0.01).治療後各時點的CGI-SI評分研究組均顯著低于對照組(P＜0.05或P＜0.01).不良反應兩組之間差異無統計學意義(P＞0.05).結論 在圍產期實施心理榦預、在產後抑鬱患病期給予艾司西酞普蘭聯閤繫統化心理治療對預防產後抑鬱和促進產後抑鬱的康複效果更好.
목적 탐토애사서태보란치료연합위산기심리간예대산후억욱적림상효과.방법 대2012년7 ～ 12월취진적493명잉산부,실시위산기심리간예,기중34례산후억욱환자작위연구조급여애사서태보란치료화계통화심리치료；대2012년1～6월미실시위산기심리간예적367명잉산부중32례산후억욱환자작위대조조급여애사서태보란치료화지지성심리치료,애사서태보란제량위10 mg/일,관찰8주.치료전급치료후1,2,4,8주말분별용한밀돈억욱량표(HAMD)화림상료효총평량표(CGI)진행평정,연후량조자료진행비교.결과 산후억욱발생솔연구조위7.7％,현저저우대조조(11.7％,x2 =3.96,P＜0.05).치료후제1、2、4、8주각시점,연구조적HAMD총분위(16.6±3.8)분、(12.4±3.2)분、(8.8±3.4)분、(6.7±2.3)분,현저저우대조조[(19.4 ±3.4)분、(14.7±3.0)분、(11.2±2.8)분、(8.2±2.7)분,t=2.43～3.15,P＜0.05혹P＜0.01).치료후각시점적CGI-SI평분연구조균현저저우대조조(P＜0.05혹P＜0.01).불량반응량조지간차이무통계학의의(P＞0.05).결론 재위산기실시심리간예、재산후억욱환병기급여애사서태보란연합계통화심리치료대예방산후억욱화촉진산후억욱적강복효과경호.
Objective To explore the clinical effects of escitalopram combined with psychological interventions during peri-parturition period for patients with postpartum depression.Methods From July to December in 2012,totally 493 pregnant women were performed psychological interventions during peri-parturition period,and 34 cases of them who suffered from postpartum depression were treated with escitalopram l0mg daily combined with systemic psychotherapy as the study group.From January to June in 2012,totally 367 pregnant women were not performed psychological interventions during peri-parturition period,and 32 cases who suffered from postpartum depression were treated with escitalopram 10 mg daily and only with support psychotherapy as the control group.Both groups were observed for 8 weeks.The Hamilton rating scale (HAMD) and Clinical Global Impression-severity of illness (CGI-SI) were tested before treatment and after 1,2,4 and 8 weeks of treatment to evaluate the efficacy.The data were compared.Results The incidence of postpartum depression was 7.7％ in the study group which was significantly lower than that in the control (11.7％,x2 =3.96,P ＜ 0.05).At different time points after treatment(at the1st,2nd,4th and 8th week),the total scores of HAMD in the study group were 16.6 ± 3.8,12.4 ±3.2,8.8 ± 3.4,6.7 ± 2.3,respectively,which were lower than those in the control with statistically significant difference (19.4 ± 3.4,14.7 ± 3.0,11.2 ± 2.8,8.2 ± 2.7,respectively,x2 =2.43-3.15,P ＜ 0.05 or P ＜ 0.01).The CGI-SI scores of different time points after treatment in the study group showed significantly lower than those in the control group(P＜ 0.05 or P＜0.01).The side-effects showed no statistical difference between the two groups (P＞ 0.05).Conclusion Psychological interventions during peri-parturition period and escitalopram treatment combined with systemic psychotherapy in depression stage had better effects on preventing and curing postpartum depression.
