CAJ | 학술논문

目的：研究不同年龄阶段脑梗死患者血清同型半胱氨酸（Hcy）、超敏C-反应蛋白（hs-CRP）、血脂水平及其相关性。方法选择2011年12月至2013年11月于该院接受治疗的脑梗死患者为研究对象共352例，将患者按年龄分为青年组、中年组、老年组，选取同期于该院进行体检的健康人员为对照组，共134例，比较4组对象的血清血脂、hs-CRP、Hcy水平及检测结果异常率并进行双变量相关性分析。结果青年组hs-CRP、Hcy水平高于对照组，而高密度脂蛋白胆固醇（HDL-C）低于对照组，差异具有统计学意义（P＜0．05）。中年组及老年组脑梗死患者低密度脂蛋白胆固醇（LDL-C）、总胆固醇（Tch）、hs-CRP及 Hcy水平明显高于对照组，而HDL-C明显低于对照组，差异具有统计学意义（P＜0．05）。青年组、中年组、老年组患者 HDL-C、hs-CRP及Hcy检测结果异常率均明显高于对照组（P＜0．05）。中年组、老年组脑梗死患者LDL-C检测结果异常率明显高于对照组，差异具有统计学意义（P＜0．05）。青年组、中年组、老年组脑梗死患者 Hcy、hs-CRP及血脂无显著相关性；HDL-C与hs-CRP呈负相关（P＜0．05）；TC与LDL-C、HDL-C及三酰甘油呈正相关（P＜0．05）。结论高同型半胱氨酸血症是脑梗死发生的独立危险因素，与血脂及hs-CRP水平无明显相关性，可作为监测疾病病情的可靠指标。
목적：연구불동년령계단뇌경사환자혈청동형반광안산（Hcy）、초민C-반응단백（hs-CRP）、혈지수평급기상관성。방법선택2011년12월지2013년11월우해원접수치료적뇌경사환자위연구대상공352례，장환자안년령분위청년조、중년조、노년조，선취동기우해원진행체검적건강인원위대조조，공134례，비교4조대상적혈청혈지、hs-CRP、Hcy수평급검측결과이상솔병진행쌍변량상관성분석。결과청년조hs-CRP、Hcy수평고우대조조，이고밀도지단백담고순（HDL-C）저우대조조，차이구유통계학의의（P＜0．05）。중년조급노년조뇌경사환자저밀도지단백담고순（LDL-C）、총담고순（Tch）、hs-CRP급 Hcy수평명현고우대조조，이HDL-C명현저우대조조，차이구유통계학의의（P＜0．05）。청년조、중년조、노년조환자 HDL-C、hs-CRP급Hcy검측결과이상솔균명현고우대조조（P＜0．05）。중년조、노년조뇌경사환자LDL-C검측결과이상솔명현고우대조조，차이구유통계학의의（P＜0．05）。청년조、중년조、노년조뇌경사환자 Hcy、hs-CRP급혈지무현저상관성；HDL-C여hs-CRP정부상관（P＜0．05）；TC여LDL-C、HDL-C급삼선감유정정상관（P＜0．05）。결론고동형반광안산혈증시뇌경사발생적독립위험인소，여혈지급hs-CRP수평무명현상관성，가작위감측질병병정적가고지표。
Objective To study the levels of serum homocysteine(Hcy) ,high-sensitivity C-reactive protein (hs-CRP) and blood lipid and their correlation in the different age stage patients with cerebral infarction .Methods 352 patients with cerebral infarction receiving treatment in the hospital from December 2011 to November 2013 were selected as the study subjects and divided into the youth group ,middle age group and elderly group by age ,with contemporaneous 134 healthy individuals of physical examination as the control group .Serum lipids ,hs-CRP ,Hcy levels and the rate of abnormal test results were compared among 4 groups and the bi-variate correlation analysis was performed .Results The serum hs-CRP ,Hcy levels in the youth group were higher than those in the control group ,while the high density lipoprotein cholesterol(HDL-C) level was lower than tha tin the control group ,the difference was statistically significant (P<0 .05) .The serum low density lipoprotein cholesterol(LDL-C) ,total cholesterol (TC) ,hs-CRP and Hcy levels in the middle age and the elderly groups were significantly higher than those in the control group ,while the HDL-C level was significantly lower than that in the control group ,the difference was statistically significant (P<0 .05) .The abnormal rates of HDL-C ,hs-CRP and Hcy test results in the youth ,middle and elderly groups were significantly higher than those in the control group with statistical difference (P< 0 .05) .The abnormal rates of LDL-C detection results in the middle age group and elderly group were significantly higher than that in the control group ,the difference was statistically significant (P<0 .05) .Hcy ,hs-CRP and lipid in the youth group ,middle group and elderly group had no significant correlation ;HDL-C was negatively correlated with hs-CRP (P<0 .05);TC was positively correlated with LDL-C ,HDL-C and triglyceride(P<0 .05) .Conclusion Hyperhomocys-teinemia is an independent risk factor for cerebral infarction occurrence ,has no significant correlation with blood lipid and hs-CRP levels ,and can be used as a reliable indicator of the disease condition monitoring .