CAJ | 학술논문

目的：研究慢性乙型肝炎（CHB）和肝硬化（LC）患者血清白细胞介素-2（IL-2）、白细胞介素-6（IL-6），白细胞介素-10（IL-10）、血清胆碱酯酶（ChE）和透明质酸（HA）变化及临床意义。方法分别检测92例CHB患者（CHB组）、63例LC患者（LC组）和46例健康人群（对照组）的血清IL-2、IL-6、IL-10、ChE和HA浓度，并且进行比较分析。结果 CHB组与LC组各型患者血清中的IL-2、IL-6和HA浓度高于对照组，而IL-10和ChE浓度低于对照组，差异均具有统计学意义（P＜0．05）；HBV DNA拷贝数量为6．0～6．9 log10 copy/mL的患者血清IL-2、IL-6和HA浓度高于拷贝数量为3．0～4．9 log10 copy/mL的患者和5．0～5．9 log10 copy/mL的患者，而IL-10和ChE浓度低于3．0～4．9 log10 copy/mL的患者和5．0～5．9 log10 copy/mL的患者，差异均具有统计学意义（P＜0．05）；Child-Pugh分级为C级的LC患者血清IL-2、IL-6和 HA浓度高于A、B级患者，而IL-10和ChE浓度低于A、B级患者，差异均具有统计学意义（P＜0．05）。结论同时检测CHB组和LC患者血清中L-2、IL-6、IL-10、ChE和HA浓度变化，能够为CHB患者病情及预后评估提供一定的临床参考价值。
목적：연구만성을형간염（CHB）화간경화（LC）환자혈청백세포개소-2（IL-2）、백세포개소-6（IL-6），백세포개소-10（IL-10）、혈청담감지매（ChE）화투명질산（HA）변화급림상의의。방법분별검측92례CHB환자（CHB조）、63례LC환자（LC조）화46례건강인군（대조조）적혈청IL-2、IL-6、IL-10、ChE화HA농도，병차진행비교분석。결과 CHB조여LC조각형환자혈청중적IL-2、IL-6화HA농도고우대조조，이IL-10화ChE농도저우대조조，차이균구유통계학의의（P＜0．05）；HBV DNA고패수량위6．0～6．9 log10 copy/mL적환자혈청IL-2、IL-6화HA농도고우고패수량위3．0～4．9 log10 copy/mL적환자화5．0～5．9 log10 copy/mL적환자，이IL-10화ChE농도저우3．0～4．9 log10 copy/mL적환자화5．0～5．9 log10 copy/mL적환자，차이균구유통계학의의（P＜0．05）；Child-Pugh분급위C급적LC환자혈청IL-2、IL-6화 HA농도고우A、B급환자，이IL-10화ChE농도저우A、B급환자，차이균구유통계학의의（P＜0．05）。결론동시검측CHB조화LC환자혈청중L-2、IL-6、IL-10、ChE화HA농도변화，능구위CHB환자병정급예후평고제공일정적림상삼고개치。
Objective To study the changes and clinical significance of serum interleukin-2 (IL-2) ,interleukin-6 (IL-6) ,interleu-kin-10 (IL-10) ,cholinesterase (ChE) and hyaluronic acid (HA) in the patients with chronic hepatitis B (CHB) and liver cirrhosis (LC) .Methods The serum concentrations of IL-2 ,IL-6 ,IL-10 ,ChE and HA were detected in 92 cases of CHB(CHB group) ,63 cases of LC (group LC) and 46 cases of healthy populations (control group) .Results The serum concentrations of IL-2 ,IL-6 and HA in the CHB group and the LC group were higher than those in the control group ,while the serum concentrations of IL-10 and ChE were lower than those in the control group ,the differences had statistical significance (P<0 .05) .The serum concentrations of IL-2 ,IL-6 and HA in the patients with HBV DNA copy number of 6 .0-6 .9 log10 copy/mL were higher than those with the copy number of 3 .0-4 .9 log10 copy/mL and 5 .0 -5 .9 log10 copy/mL ,while the serum concentrations of IL-10 and ChE were lower than those with HBV DNA copy number of 3 .0-4 .9 log10 copy/mL and 5 .0-5 .9 log10 copy/mL ,the differences had statistical significance(P<0 .05) .The serum concentrations of IL-2 ,IL-6 and HA in the LC patients with the Child-Pugh grade C were higher than those with the Child-Pugh grade A and B ,while serum concentrations of IL-10 and ChE were lower than those with the Child-Pugh grade A and B ,the differences were statistically significant (P<0 .05) .Conclusion The simultaneous detection of serum IL-2 ,IL-6 ,IL-10 ,ChE and HA concentration changes can provide certain clinical reference value for the evaluation of severity and prognosis in the patients with CHB and LC .