CAJ | 학술논문

目的：探讨人附睾上皮分泌蛋白4（HE4）和肿瘤相关糖类抗原125（CA125）联合检测在卵巢癌的诊断和鉴别诊断中的应用价值。方法采用化学发光免疫法检测51例卵巢癌患者和37例卵巢良性病变患者血清CA125，用酶联免疫法检测 HE4水平，另设40例健康体检女性为健康对照组，检测数据结合临床资料进行统计学分析。结果卵巢癌组患者的血清HE4、CA125水平均显著高于卵巢良性病变组和健康对照组（P＜0．01）。Ⅲ～Ⅳ期患者的血清浓度显著高于Ⅰ～Ⅱ期（P＜0．01）。联检 HE4和CA125诊断卵巢癌的敏感度为84．6％，特异度为83．9％，准确度为89．4％，敏感度和准确度相比任一单项检测均得到提高，特异度与单项检测CA125时保持一致。结论联合检测血清HE4和CA125有助于提高卵巢癌的诊断效能，对卵巢肿瘤的良恶性鉴别诊断具有一定应用价值。
목적：탐토인부고상피분비단백4（HE4）화종류상관당류항원125（CA125）연합검측재란소암적진단화감별진단중적응용개치。방법채용화학발광면역법검측51례란소암환자화37례란소량성병변환자혈청CA125，용매련면역법검측 HE4수평，령설40례건강체검녀성위건강대조조，검측수거결합림상자료진행통계학분석。결과란소암조환자적혈청HE4、CA125수평균현저고우란소량성병변조화건강대조조（P＜0．01）。Ⅲ～Ⅳ기환자적혈청농도현저고우Ⅰ～Ⅱ기（P＜0．01）。련검 HE4화CA125진단란소암적민감도위84．6％，특이도위83．9％，준학도위89．4％，민감도화준학도상비임일단항검측균득도제고，특이도여단항검측CA125시보지일치。결론연합검측혈청HE4화CA125유조우제고란소암적진단효능，대란소종류적량악성감별진단구유일정응용개치。
Objective To investigate the application value of the combined detection of the serum levels of tumor-associated car-bohydrate antigen 125(CA125) and human epididymis epithelial secretory protein 4 (HE4) in the diagnosis and the differentiation diagnosis of ovarian cancer .Methods Serum levels of CA125 and HE4 in 51 patients with ovarian cancer ,37 patients with benign ovarian tumor and 40 healthy females as the healthy control group were measured by chemiluminescent immunoassay (CLIA) and enzyme linked immunosorbent assay(ELISA) respectively .The detection results combined with the clinical data were performed the statistical analysis .Results The serum levels of CA125 and HE4 in the ovarian cancer group were significantly higher than those in the benign ovarian tumor group and the healthy control group (P<0 .01) .Serum concentration in the stage Ⅲ - Ⅳwere higher than that in the stage Ⅰ - Ⅱ(P<0 .01) .In the combined detection of HE4 and CA125 ,the sensitivity ,specificity and accuracy for diag-nosing ovarian cancer were 84 .6% ,83 .9% and 89 .4% respectively .Their sensitivity and accuracy were higher than those of any single marker detection ,the specificity was consistent with that in the single CA 125 detection .Conclusion The combined detection of serum CA125 and HE4 is conducive to increase the diagnosis efficiency and has certain application value in the differential diag-nosis of benign and malignant ovarian tumor .