CAJ | 학술논문

目的：研究性早熟女童血清胃饥饿素（ghrelin）与性激素水平变化。方法87例性早熟女童根据促性腺激素释放激素（GnRH）激发试验结果及卵巢、子宫、第二性征发育情况等分为单纯性乳房早发育（SPT）组和中枢性性早熟（CPP）组，34例年龄匹配的健康女童作为对照组，血清ghrelin采用酶联免疫吸附试验定量法测定，黄体生成素（LH）、促卵泡激素（FSH）、雌二醇（E2）、孕酮（PRGE）、泌乳素（PRL）、睾酮（TSTO）及GnRH激发后30、60、90 min的LH、FSH采用化学发光法测定。结果 CPP组血清ghrelin明显高于对照组（P＜0．05）；SPT组与对照组、CPP组与SPT组比较差异均无统计学意义（P＞0．05）。CPP 组血清性激素5项（LH、FSH、E2、PRL、PRGE）明显高于对照组和SPT组（P＜0．05），SPT 组和对照组血清性激素5项比较差异无统计学意义（P＞0．05）；3组的 TSTO比较差异无统计学意义（P＞0．05）。结论 CPP 女童血清ghrelin及性激素5项LH、FSH、E2、PRL、PRGE水平明显升高。
목적：연구성조숙녀동혈청위기아소（ghrelin）여성격소수평변화。방법87례성조숙녀동근거촉성선격소석방격소（GnRH）격발시험결과급란소、자궁、제이성정발육정황등분위단순성유방조발육（SPT）조화중추성성조숙（CPP）조，34례년령필배적건강녀동작위대조조，혈청ghrelin채용매련면역흡부시험정량법측정，황체생성소（LH）、촉란포격소（FSH）、자이순（E2）、잉동（PRGE）、비유소（PRL）、고동（TSTO）급GnRH격발후30、60、90 min적LH、FSH채용화학발광법측정。결과 CPP조혈청ghrelin명현고우대조조（P＜0．05）；SPT조여대조조、CPP조여SPT조비교차이균무통계학의의（P＞0．05）。CPP 조혈청성격소5항（LH、FSH、E2、PRL、PRGE）명현고우대조조화SPT조（P＜0．05），SPT 조화대조조혈청성격소5항비교차이무통계학의의（P＞0．05）；3조적 TSTO비교차이무통계학의의（P＞0．05）。결론 CPP 녀동혈청ghrelin급성격소5항LH、FSH、E2、PRL、PRGE수평명현승고。
Objective To investigate the change of serum ghrelin and sex hormones levels in girls with precocious puberty . Methods 87 girls with precocious puberty were divided into the simple premature thelarche (SPT ) and central precocious puberty (CPP) groups according to the results of gonadotropin releasing hormone(GnRH) stimulation test ,size of ovary and uterus ,and de-velopmental status of the secondary sex characteristics ,with 34 age-matched healthy girls as control group .The serum ghrelin level was quantitatively measured by enzyme-linked immunosorbent assay (ELISA) ,luteinizing hormone(LH) ,follicle stimulating hor-mone(FSH) ,estradiol(E2) ,progesterone(PRGE) ,prolactin (PRL) ,testosterone (TSTO) and LH and FSH stimulated by GnRH after 30 ,60 ,90 min were measured by chemoluminescence technique .Results The ghrelin level in the CPP group was significantly higher than that in the control group(P<0 .05);there was no statistically significant difference between the SPT group and the control group and between the CPP group and the SPT group (P>0 .05) .The 5 indexes of sex hormone (LH ,FSH ,E2 ,PRL , PRGE) in the CPP group were significantly higher than those in the SPT group and the control group (P<0 .05) ,but no statisti-cally significant difference existed between the SPT group and the control group (P>0 .05);the TSTO level had no statistically sig-nificant difference among 3 groups(P>0 .05) .Conclusion The serum levels of ghrelin and 5 indexes of sex hormone (LH ,FSH , E2 ,PRL ,PRGE) in girls with CPP are significantly increased .