实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
15期
2481-2483
,共3页
心肌梗死%介入治疗%替罗非班%sCD40L%HIF-1α%iNOS
心肌梗死%介入治療%替囉非班%sCD40L%HIF-1α%iNOS
심기경사%개입치료%체라비반%sCD40L%HIF-1α%iNOS
Myocardial infarction%Intervention%Tirofiban%sCD40L%HIF-1α%iNOS
目的：观察替罗非班对行急诊 PCI 术患者血清可溶性 CD40配体（ sCD40L ）、缺氧诱导因子（HIF-1α）浓度及诱导性一氧化氮合成酶（iNOS）活性的影响。方法：80例接受直接PCI术的急性ST段抬高型心肌梗死患者，随机分为替罗非班组和对照组，每组40例；替罗非班组：术中球囊扩张后支架植入前冠脉内注入10μg/kg 替罗非班，术后以维持量0．15μg/（kg·min）持续微量泵泵入24～36 h；对照组：球囊扩张术后直接行支架植入术。测定两组患者PCI术前、术后12 h sCD40L、HIF-lα、iNOS的水平。结果：术后12 h血清 sCD40L、HIF-1α、iNOS 水平高于 PCI 术前（ P ＜0．05）。与对照组比较，替罗非班组血清 sCD40L、HIF-1α、iNOS水平明显降低（P＜0．05）。结论：本研究初步提示了替罗非班不但具有抗血小板聚集作用，而且还能抗炎和保护血管内皮。
目的：觀察替囉非班對行急診 PCI 術患者血清可溶性 CD40配體（ sCD40L ）、缺氧誘導因子（HIF-1α）濃度及誘導性一氧化氮閤成酶（iNOS）活性的影響。方法：80例接受直接PCI術的急性ST段抬高型心肌梗死患者，隨機分為替囉非班組和對照組，每組40例；替囉非班組：術中毬囊擴張後支架植入前冠脈內註入10μg/kg 替囉非班，術後以維持量0．15μg/（kg·min）持續微量泵泵入24～36 h；對照組：毬囊擴張術後直接行支架植入術。測定兩組患者PCI術前、術後12 h sCD40L、HIF-lα、iNOS的水平。結果：術後12 h血清 sCD40L、HIF-1α、iNOS 水平高于 PCI 術前（ P ＜0．05）。與對照組比較，替囉非班組血清 sCD40L、HIF-1α、iNOS水平明顯降低（P＜0．05）。結論：本研究初步提示瞭替囉非班不但具有抗血小闆聚集作用，而且還能抗炎和保護血管內皮。
목적：관찰체라비반대행급진 PCI 술환자혈청가용성 CD40배체（ sCD40L ）、결양유도인자（HIF-1α）농도급유도성일양화담합성매（iNOS）활성적영향。방법：80례접수직접PCI술적급성ST단태고형심기경사환자，수궤분위체라비반조화대조조，매조40례；체라비반조：술중구낭확장후지가식입전관맥내주입10μg/kg 체라비반，술후이유지량0．15μg/（kg·min）지속미량빙빙입24～36 h；대조조：구낭확장술후직접행지가식입술。측정량조환자PCI술전、술후12 h sCD40L、HIF-lα、iNOS적수평。결과：술후12 h혈청 sCD40L、HIF-1α、iNOS 수평고우 PCI 술전（ P ＜0．05）。여대조조비교，체라비반조혈청 sCD40L、HIF-1α、iNOS수평명현강저（P＜0．05）。결론：본연구초보제시료체라비반불단구유항혈소판취집작용，이차환능항염화보호혈관내피。
Objective To observe the impacts of tirofiban on plasma levels of sCD40L and HIF-1α, and iNOS activity in patients undergoing emergency PCI. Methods A total of 80 patients with acute STEMI received primary PCI were randomly divided into a tirofiban group and a control group. The tirofiban group received tirofiban of 10 μg/kg, followed by an infusion of tirofiban of 0.15 μg/(kg·min) for 24 ~ 36 hours; while the control group directly received stent implantation after balloon angioplasty. Plasma levels of sCD40L , HIF-1α, and iNOS were detected in baselines and 12 hours after the procedrue. Results 12 hours after the procedure, serum levels of sCD40L, HIF-1α, and iNOS were higher than the baseline levels (P < 0.05). As compared with the control group, levels of sCD40L, HIF-1α, and iNOS were significantly lower (P < 0.05). Conclusions This study preliminarily sugguests tirofiban has a role in anti-inflammation and protection of vascular endothelium besides anti-platelet effects.
