CAJ | 학술논문

目的：通过检测 P16基因在宫颈癌中的表达，分析 P16基因与宫颈癌预后的关系，评价 P16基因在宫颈癌预后预测中的价值。方法：采用免疫组织化学SP法检测P16基因在74例宫颈癌患者组织中的表达，并对P16基因表达与宫颈癌预后的关系进行相关性分析。结果：74例宫颈癌病例中，P16基因的表达阳性率为85％（63/74），P16基因阳性表达与宫颈癌预后呈正相关（P＝0．041）。 P16基因阳性表达组2年累积生存率为85．2％，P16基因阴性表达组2年累积生存率为100％。 P16基因阳性表达组2年累积生存率低于P16基因阴性表达组（P＝0．043），两者比较有统计学意义。 P16基因阳性表达与临床分期、间质浸润及LVSI呈正相关（P＜0．05），而与TNM及组织分化无相关性（P＞0．05）。结论：P16基因的阳性表达与宫颈癌患者的预后密切相关，可作为预测宫颈癌预后的指标之一。
목적：통과검측 P16기인재궁경암중적표체，분석 P16기인여궁경암예후적관계，평개 P16기인재궁경암예후예측중적개치。방법：채용면역조직화학SP법검측P16기인재74례궁경암환자조직중적표체，병대P16기인표체여궁경암예후적관계진행상관성분석。결과：74례궁경암병례중，P16기인적표체양성솔위85％（63/74），P16기인양성표체여궁경암예후정정상관（P＝0．041）。 P16기인양성표체조2년루적생존솔위85．2％，P16기인음성표체조2년루적생존솔위100％。 P16기인양성표체조2년루적생존솔저우P16기인음성표체조（P＝0．043），량자비교유통계학의의。 P16기인양성표체여림상분기、간질침윤급LVSI정정상관（P＜0．05），이여TNM급조직분화무상관성（P＞0．05）。결론：P16기인적양성표체여궁경암환자적예후밀절상관，가작위예측궁경암예후적지표지일。
Objective To access the expression of germ P16 in cervical cancer patients , find out the connection between with the expression in germ of P16 and the prognosis of cervical cancer , and discuss whether P16 can role as an indicator to predict the prognosis. Methods The pathological sections of all 74 cases were tested for the presence of P16 germ , using an immunohistochemistry technique. And the results were analyzed to investigate the value of P16 on the prediction of prognosis of cervical cancer. Results Of all 74 cervical cancer cases, there are 63 cases show positive expression of P16, with the positive expression rate of 85% (63/74). The positive expression of gene P16 is associated with the prognosis of cervical cancer (P = 0.041). The cumulative survival rate for two years of the positive expression set is 85.2%, and the negative set 100%, which is statistically significant (P = 0.043). Positiveexpression of P16 is closely related (P < 0.05) with clinical stages LVSI and interstitial infiltrates, but is irrelevant (P > 0.05) with TNM and histological differentiation. Conclusions We suggest that the expression of germ P16 is closely connected prognosis in cervical cancer , and it might be used as one of indicator to predict the prognosis of cervical cancer.