CAJ | 학술논문

目的：探讨三氧化二砷能否增强顺铂对口腔癌细胞的抗瘤活性。方法：以人口腔癌细胞株HSQ-89为研究对象，在经顺铂处理过的肿瘤细胞中加入不同浓度的三氧化二砷，用 MTT 法测定计算肿瘤细胞的抑制率。结果：在加入顺铂15μg/mL的口腔癌细胞珠HSQ-89中加入不同浓度的三氧化二砷0、2．5、5、7．5、10、12．5μmol/mL，肿瘤细胞的抑制率分别为26．9％、67．5％、73．0％、88．5％、90．4％、98．7％；三氧化二砷与顺铂联用，可以提高对HSQ-89细胞的抑制率，并呈剂量依赖性增加。结论：三氧化二砷与顺铂联用，对口腔癌细胞的生长抑制具有协同效应。
목적：탐토삼양화이신능부증강순박대구강암세포적항류활성。방법：이인구강암세포주HSQ-89위연구대상，재경순박처리과적종류세포중가입불동농도적삼양화이신，용 MTT 법측정계산종류세포적억제솔。결과：재가입순박15μg/mL적구강암세포주HSQ-89중가입불동농도적삼양화이신0、2．5、5、7．5、10、12．5μmol/mL，종류세포적억제솔분별위26．9％、67．5％、73．0％、88．5％、90．4％、98．7％；삼양화이신여순박련용，가이제고대HSQ-89세포적억제솔，병정제량의뢰성증가。결론：삼양화이신여순박련용，대구강암세포적생장억제구유협동효응。
Objective To discuss the anticancer role of arsenic trioxide (ATO) with cisplatin on human oral carcinoma HSQ-89 cells. Methods The human oral epidermoid HSQ-89 cells were chosen as the subjects. Different concentrations of ATO were added into Cisplatin(DDP)-treated cells. The inhibition rate of tumor cells was detected by MTT assay. Results Different concentrations of ATO (0,2.5,5,7.5,10,12.5 μmol/mL) were added into oral cancer HSQ-89 cells which have been treated with DDP (15 μg/mL). The inhibition rate of tumor cells were 26.9%, 67.5%, 73.0%, 88.5%, 90.4%, 98.7%respectively; The combined application of ATO with cisplatin could improve the inhibition rate of HSQ-89 cells in a dose-dependent relation. Conclusion The combined application of ATO and DDP can produce a synergistic action of inhibition on oral cancer cell.