中成药辨证论治慢性肾脏病3-4期的多中心前瞻性临床研究
중성약변증론치만성신장병3-4기적다중심전첨성림상연구
Prospective multicenter study on syndrome differentiation-based treatment with traditional Chinese medicine for Chronic Kidney Disease (CKD3-4)
  • 万方数据
    实用医学杂志 실용의학잡지
    THE JOURNAL OF PRACTICAL MEDICINE
    2014年 16期 2658-2662 ,共5页

    孟元%张胜容%刘宝利%李靖%赵轶雯%王雨%赵静%赵文景%葛楠%杨彦芳%刘洋%任建伟%程虹%刘建平

    맹원%장성용%류보리%리정%조질문%왕우%조정%조문경%갈남%양언방%류양%임건위%정홍%류건평

    慢性肾脏病%3-4期%中成药%辨证论治 慢性腎髒病%3-4期%中成藥%辨證論治
    만성신장병%3-4기%중성약%변증론치
    Chronic Kidney Disease (CKD3-4)%Chinese Traditional Patent Medicine%Syndrome differentiation-based treatment
    目的：研究中成药辨证论治对CKD3-4期患者的临床疗效。方法：采用前瞻性多中心随机对照研究的方法，将符合方案的339例患者，分为规范组167例、对照组172例，规范组按辨证论治方案予中成药单方或组方口服；对照组予经验中成药单方口服；观察24周后两组的临床疗效。结果：CKD3期规范组治疗后血肌酐、肾小球滤过率估算值、24 h尿蛋白定量均有统计学意义（P ＜0．05）；对照组无明显变化（P ＞0．05），规范组优于对照组；CKD4期规范组与治疗组，组内、组间比较均无统计学差异（P ＞0．05）。 CKD3-4期规范组治疗后的中医证候积分均较基线时明显改善（P＜0．05），而对照组无统计学意义（P ＞0．05），规范组较对照组中医证候积分下降更明显（P ＜0．05）。结论：中成药辨证论治对CKD3-4期患者在保护肾功能、减少尿蛋白、降低证候积分方面优于经验用药治疗。
    목적：연구중성약변증론치대CKD3-4기환자적림상료효。방법：채용전첨성다중심수궤대조연구적방법，장부합방안적339례환자，분위규범조167례、대조조172례，규범조안변증론치방안여중성약단방혹조방구복；대조조여경험중성약단방구복；관찰24주후량조적림상료효。결과：CKD3기규범조치료후혈기항、신소구려과솔고산치、24 h뇨단백정량균유통계학의의（P ＜0．05）；대조조무명현변화（P ＞0．05），규범조우우대조조；CKD4기규범조여치료조，조내、조간비교균무통계학차이（P ＞0．05）。 CKD3-4기규범조치료후적중의증후적분균교기선시명현개선（P＜0．05），이대조조무통계학의의（P ＞0．05），규범조교대조조중의증후적분하강경명현（P ＜0．05）。결론：중성약변증론치대CKD3-4기환자재보호신공능、감소뇨단백、강저증후적분방면우우경험용약치료。
    Objective To study the clinical curative effect of syndrome differentiation-based treatment with traditional Chinese medicine on patient with Chronic Kidney Disease (CKD3-4). Method According to prospective multicenter randomized controlled study which was applied to the patients with CKD3-4 , the total of 339 patients were divided into two groups. To one group as standard including 167 patients ,the other including 172 patients. Chinese Traditional Patent Medicine single or combined-prescription oral treatment according to syndrome differentiation-based treatment was employed. To the other group as reference , Chinese Traditional Patent Medicine oral treatment according to experienced rule was applied. The clinical curative effect results were obtained after a 24 weeks-treatment. Result The Scr ,eGFR and UTP with CKD3 in standard group illustrate statistics significance (P<0.05). On the opposite, those of the reference group remain insignificance (P > 0.05). The clinical curative effect result of patient in standard group was better than that of reference group. About the clinical curative effect of CKD4, no statistics significance difference (P > 0.05) could be found between groups or between patients in one group. The TCM score of patient with CKD3-4 in standard group have improved (P < 0.05) according to baseline. However, that of reference group did not show any statistics significance (P > 0.05). Conclusion Syndrome differentiation-based treatment with traditional Chinese medicine illustrated a better result in protection of renal function, reduction in urinary protein and decline in TCM score than the treatment according to experienced rule.
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