实用医学杂志
實用醫學雜誌
실용의학잡지
THE JOURNAL OF PRACTICAL MEDICINE
2014年
16期
2619-2622
,共4页
王莉云%靳隽%王辉%党小红
王莉雲%靳雋%王輝%黨小紅
왕리운%근준%왕휘%당소홍
TPO-Ab%体外受精-胚胎移植%流产%妊娠
TPO-Ab%體外受精-胚胎移植%流產%妊娠
TPO-Ab%체외수정-배태이식%유산%임신
TPO-Ab%In vitro fertilization embryo transfer%Abortion%pregnancy
目的:研究甲状腺过氧化物酶抗体(thyroid peroxidase-Ab, TPO-Ab)对体外受精-胚胎移植(in vitro fertilization and Embryo transfer , IVF-ET )结局的影响。方法:分析2011年3月至2013年10月期间在青海省人民医院生殖中心接受体外受精-胚胎移植患者共计378个助孕周期资料。甲状腺过氧化物酶抗体阳性且甲状腺功能正常患者69个周期作为研究组(A 组),甲状腺过氧化物酶抗体阴性且甲状腺功能正常者309个周期作为对照组(B 组)。结果:TPO-Ab 阳性组与对照组两组间IVF受精率(79.76%vs.84.08%),优质胚胎率(46.59% vs.54.49%),TPO-Ab 阳性组明显低于 TPO-Ab 阴性组,差异有统计学意义(P <0.05);TPO-Ab阳性组的流产率(33.33%)明显高于TPO-Ab阴性组(16.11%),差异有统计学意义(P<0.05)。结论:甲状腺过氧化物酶抗体阳性可降低IVF受精率及优胚率、增加流产率对IVF-ET结局有不利影响。
目的:研究甲狀腺過氧化物酶抗體(thyroid peroxidase-Ab, TPO-Ab)對體外受精-胚胎移植(in vitro fertilization and Embryo transfer , IVF-ET )結跼的影響。方法:分析2011年3月至2013年10月期間在青海省人民醫院生殖中心接受體外受精-胚胎移植患者共計378箇助孕週期資料。甲狀腺過氧化物酶抗體暘性且甲狀腺功能正常患者69箇週期作為研究組(A 組),甲狀腺過氧化物酶抗體陰性且甲狀腺功能正常者309箇週期作為對照組(B 組)。結果:TPO-Ab 暘性組與對照組兩組間IVF受精率(79.76%vs.84.08%),優質胚胎率(46.59% vs.54.49%),TPO-Ab 暘性組明顯低于 TPO-Ab 陰性組,差異有統計學意義(P <0.05);TPO-Ab暘性組的流產率(33.33%)明顯高于TPO-Ab陰性組(16.11%),差異有統計學意義(P<0.05)。結論:甲狀腺過氧化物酶抗體暘性可降低IVF受精率及優胚率、增加流產率對IVF-ET結跼有不利影響。
목적:연구갑상선과양화물매항체(thyroid peroxidase-Ab, TPO-Ab)대체외수정-배태이식(in vitro fertilization and Embryo transfer , IVF-ET )결국적영향。방법:분석2011년3월지2013년10월기간재청해성인민의원생식중심접수체외수정-배태이식환자공계378개조잉주기자료。갑상선과양화물매항체양성차갑상선공능정상환자69개주기작위연구조(A 조),갑상선과양화물매항체음성차갑상선공능정상자309개주기작위대조조(B 조)。결과:TPO-Ab 양성조여대조조량조간IVF수정솔(79.76%vs.84.08%),우질배태솔(46.59% vs.54.49%),TPO-Ab 양성조명현저우 TPO-Ab 음성조,차이유통계학의의(P <0.05);TPO-Ab양성조적유산솔(33.33%)명현고우TPO-Ab음성조(16.11%),차이유통계학의의(P<0.05)。결론:갑상선과양화물매항체양성가강저IVF수정솔급우배솔、증가유산솔대IVF-ET결국유불리영향。
Objective To Study the effect of thyroid peroxidase-Ab (TPO-Ab) on in vitro fertilization and embryo transfer (IVF-ET) ending. Methods From March 2011 to October 2013, a total of 378 assisted reproduction cycles in Reproductive Medical Center of Qinghai Provincial People ’s Hospital were retrospectively analyzed in. Experiment group included 69 cycles from patients with positive thyroid peroxidase antibody and normal thyroid function and control group 309 cycles from those with negative thyroid peroxidase antibody and normal thyroid function. Results IVF fertility rate (79.76%) and high quality embryo rate (46.59%) in experiment group were significantly lower than those in control group (84.08%, 54.49% respectively) and the difference was statistically significant (P < 0.05); abortion rate (33.33%) in experiment group was obviously higher than that in control group (16.11%), which was statistically significant (P < 0.05). Conclusion Positive thyroid peroxidase antibody exerts adverse effects on IVF-ET ending since TPO-Ab reduces IVF fertilization rate and high quality embryo rate and increases the rate of abortion.