CAJ | 학술논문

目的：采用微波加热方式溶解20％甘露醇注射液内的结晶，观察不同火力档位下其结晶溶解情况，以期找到溶解规律。方法将重新产生结晶的软塑袋包装的甘露醇注射液放入微波炉内进行加热，设解冻、中低火、中火、中高火、高火四档，设时间点 t＝15 s、30 s、45 s……420 s ，加热到每个时间点立即以称量法计算20％甘露醇溶液中残余结晶量；另在时间点 t＝120 s、180 s、240 s……420 s时，以煤油温度计测量袋内溶液温度；每火力档位下的每个时间点重复实验3次，计算平均值并绘制图表。结果以不同的火力档位加热溶解甘露醇结晶，在即将爆袋前均未能将甘露醇结晶完全溶解掉，结晶残余量为0．86～3．56 g ；在加热到最高时间点时（即将爆袋前）溶液温度均达到了90℃以上。结论20％甘露醇注射液内的结晶不宜采用微波加热方法溶解，加热后的袋装甘露醇溶液温度高不能用手直接取出，且极有可能发生爆袋，会对人员造成烫伤，既有危险又浪费人力和精力。
목적：채용미파가열방식용해20％감로순주사액내적결정，관찰불동화력당위하기결정용해정황，이기조도용해규률。방법장중신산생결정적연소대포장적감로순주사액방입미파로내진행가열，설해동、중저화、중화、중고화、고화사당，설시간점 t＝15 s、30 s、45 s……420 s ，가열도매개시간점립즉이칭량법계산20％감로순용액중잔여결정량；령재시간점 t＝120 s、180 s、240 s……420 s시，이매유온도계측량대내용액온도；매화력당위하적매개시간점중복실험3차，계산평균치병회제도표。결과이불동적화력당위가열용해감로순결정，재즉장폭대전균미능장감로순결정완전용해도，결정잔여량위0．86～3．56 g ；재가열도최고시간점시（즉장폭대전）용액온도균체도료90℃이상。결론20％감로순주사액내적결정불의채용미파가열방법용해，가열후적대장감로순용액온도고불능용수직접취출，차겁유가능발생폭대，회대인원조성탕상，기유위험우낭비인력화정력。
Objective To observe state of crystals dissolved by adopting microwave heating to dissolve crystalliza-tion 20% mannitol injection under different fire position of microwave oven .Method Regenerated crystallization of 20% mannitol injection was packaged with soft plastic bag and placed in the microwave oven for heating .After heat-ing ,residual amount of crystallization of 20% mannitol injection was immediately weighed based set heating and time point ,such the defrost ,low ,midst ,high ,highest fire position ,and set up time point t=15 s ,30 s ,45 s… …420 s .In another hand ,kerosene thermometer was used to measure the temperature of solution within the plastic bag at the time point t=120 s ,180 s ,240 s… …420 s .Each experiment is repeated three times at each time point . Result Mannitol crystals are not dissolved completely by heating before bags explosion in different firepower .Quality of crystalline residue is 0 .86 g to 3 .56 g .The solution temperature exceed 90 ℃ by heated to the highest time point (before the bags burst) .Conclusion 20% mannitol injection should not be suitable for microwave heating to dissolve the crystals .Mannitol solution can not be directly removed by hand after heating due to the high temperature and to avoid the possible bag explosion and cause burns personnel .