CAJ | 학술논문

目的：分析川东北地区2005～2012年女性生殖道沙眼衣原体（CT）、淋球菌（NG）和解脲脲原体（UU）感染状况及变化趋势，为该类患者的诊断和治疗提供实验室依据。方法应用实时荧光定量PCR（RT-PCR）技术对1386例女性生殖道标本进行CT、NG、UU病原体DNA检测，并对结果进行统计分析。结果3种病原体的总阳性率为62．8％（871/1386）。单纯感染中以UU阳性率最高，为48．0％（665/1386）；CT、NG阳性率为仅为2．2％。混合感染以CT＋UU阳性率最高，为6．5％（90/1386）；UU＋NG阳性率为2．5％（35/1386）；CT＋NG阳性率为0．4％（5/1386）；CT＋UU＋NG阳性率为1．1％（15/1386）。不同年龄段中，小于20岁组阳性率为49．3％，而大于20岁组中均超过60％。2005～2012年间，女性CT、NG、UU病原体阳性率持续高水平且总体呈上升趋势。结论CT和UU是该地区女性生殖道感染的主要病原体，并以20岁以上生殖道感染者阳性率均较高，3种病原体感染率呈逐年上升趋势，应该重视该人群CT和UU的检测以指导临床医师对患者的诊断和治疗。
목적：분석천동북지구2005～2012년녀성생식도사안의원체（CT）、림구균（NG）화해뇨뇨원체（UU）감염상황급변화추세，위해류환자적진단화치료제공실험실의거。방법응용실시형광정량PCR（RT-PCR）기술대1386례녀성생식도표본진행CT、NG、UU병원체DNA검측，병대결과진행통계분석。결과3충병원체적총양성솔위62．8％（871/1386）。단순감염중이UU양성솔최고，위48．0％（665/1386）；CT、NG양성솔위부위2．2％。혼합감염이CT＋UU양성솔최고，위6．5％（90/1386）；UU＋NG양성솔위2．5％（35/1386）；CT＋NG양성솔위0．4％（5/1386）；CT＋UU＋NG양성솔위1．1％（15/1386）。불동년령단중，소우20세조양성솔위49．3％，이대우20세조중균초과60％。2005～2012년간，녀성CT、NG、UU병원체양성솔지속고수평차총체정상승추세。결론CT화UU시해지구녀성생식도감염적주요병원체，병이20세이상생식도감염자양성솔균교고，3충병원체감염솔정축년상승추세，응해중시해인군CT화UU적검측이지도림상의사대환자적진단화치료。
Objective To analyze the infection status and variation tendency of chlamydia trachomatis (CT) ,Neisseria gonorrhoe-ae(NG) and ureaplasma urealyticum(UU) in female genital tract in northeast Sichuan province during 2005 -2012 to provide the laboratory basis for their diagnosis and treatment Methods The real-time fluorescent quantitative PCR (RT-PCR) was applied to detect the CT DNA ,NG DNA and UU DNA in 1 386 samples from female genital tract and the detection results were performed the statistical analysis .Results The total positive rate of these 3 kinds of pathogens was 62 .8% (871/1 386) .Among the simple in-fection ,UU had the highest positive rate(48 .0% ,665/1 386);the positive rates of CT and NG were only 2 .2% .In the mixed infec-tion ,the positive rate of CT + UU was highest(6 .5% ,90/1 386) ,while which of UU + NG ,CT + NG and CT+ NG+ UU was 2 .5% (35/1 386) ,0 .4% (5/1 386) and 1 .1% (15/1 386) respectively .In different age groups ,the positive rate in the age <20 years old group was 49 .3% ,while which in the age >20 years old groups were all more than 60% .The positive rate of the CT ,NG and UU pathogens in females was in continuous high level during 2005 -2012 ,and which totally showed an increasing tendency . Conclusion CT and UU are the main pathogens in female genital tract infection in this region ,and the positive rate of genital tract infection in females aged more than 20 years is higher ,the infection rate of these 3 kinds of pathogens demonstrates the increasing trend year by year ,so more attention should be paid to the detection of CT and UU in this group for guiding the clinicians to con-duct the diagnosis and treatment .