山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
29期
12-14
,共3页
张亚男%张伟兵%田晓彦%张慧%赵春雨%李响%刘长萍
張亞男%張偉兵%田曉彥%張慧%趙春雨%李響%劉長萍
장아남%장위병%전효언%장혜%조춘우%리향%류장평
肺疾病,慢性阻塞性%盐酸氨溴索%细胞因子
肺疾病,慢性阻塞性%鹽痠氨溴索%細胞因子
폐질병,만성조새성%염산안추색%세포인자
pulmonary disease,chronic obstructive%ambroxol%cytokines
目的：观察不同剂量沐舒坦对老年慢性阻塞性肺疾病急性加重期（ AECOPD ）痰液中炎性细胞因子（ IL-6、IL-8、TNF-α）的影响，旨在寻找最佳治疗效果的最小沐舒坦剂量。方法选择老年AECOPD患者194例，随机分成4组，每组50例。其中，A、B、C组分别给予沐舒坦30、90、330 mg/次，D组给予若通4 mg/次，3次/d，连续静滴7 d。分别观察各组入院第1、4、7天痰液中IL-6、IL-8、TNF-α水平的变化。结果与A、B、D组比较，C组于入院第4天和第7天痰液中IL-6、IL-8、TNF-α下降最明显（P均＜0．05）；A、B、D组入院第4天与入院第7天，痰液中IL-6、IL-8、TNF-α变化不明显（P均＞0．05）。结论短期大剂量应用沐舒坦能显著降低老年AECOPD患者痰液中IL-6、IL-8、TNF-α水平，具有良好的抗炎作用。
目的：觀察不同劑量沐舒坦對老年慢性阻塞性肺疾病急性加重期（ AECOPD ）痰液中炎性細胞因子（ IL-6、IL-8、TNF-α）的影響，旨在尋找最佳治療效果的最小沐舒坦劑量。方法選擇老年AECOPD患者194例，隨機分成4組，每組50例。其中，A、B、C組分彆給予沐舒坦30、90、330 mg/次，D組給予若通4 mg/次，3次/d，連續靜滴7 d。分彆觀察各組入院第1、4、7天痰液中IL-6、IL-8、TNF-α水平的變化。結果與A、B、D組比較，C組于入院第4天和第7天痰液中IL-6、IL-8、TNF-α下降最明顯（P均＜0．05）；A、B、D組入院第4天與入院第7天，痰液中IL-6、IL-8、TNF-α變化不明顯（P均＞0．05）。結論短期大劑量應用沐舒坦能顯著降低老年AECOPD患者痰液中IL-6、IL-8、TNF-α水平，具有良好的抗炎作用。
목적：관찰불동제량목서탄대노년만성조새성폐질병급성가중기（ AECOPD ）담액중염성세포인자（ IL-6、IL-8、TNF-α）적영향，지재심조최가치료효과적최소목서탄제량。방법선택노년AECOPD환자194례，수궤분성4조，매조50례。기중，A、B、C조분별급여목서탄30、90、330 mg/차，D조급여약통4 mg/차，3차/d，련속정적7 d。분별관찰각조입원제1、4、7천담액중IL-6、IL-8、TNF-α수평적변화。결과여A、B、D조비교，C조우입원제4천화제7천담액중IL-6、IL-8、TNF-α하강최명현（P균＜0．05）；A、B、D조입원제4천여입원제7천，담액중IL-6、IL-8、TNF-α변화불명현（P균＞0．05）。결론단기대제량응용목서탄능현저강저노년AECOPD환자담액중IL-6、IL-8、TNF-α수평，구유량호적항염작용。
Objective To observe the effects of different doses of ambroxol on cytokines ( IL-6, IL-8 and TNF-α) in the sputum from elderly patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to find the minimum dose of ambroxol with the best treatment effect .Methods Totally 194 cases of elderly patients with AECOPD were selected and were randomly divided into four groups , 50 cases in each group:groups A, B, C and D.Patients in the groups A, B and C were given 30, 90 and 330 mg/sub ambroxol;patients in the group D were treated with bromhexine 4 mg/sub, three times a day;and all patients were continuously treated with intravenous infusion for seven days .The chan-ges of IL-6, IL-8 and TNF-αin each group on the first day , the forth day and the seventh day of hospitalization were ob-served.Results Compared with groups A , B and D, IL-6、IL-8 and TNF-αon the forth day and the seventh day in the group C had the greatest reduction (all P<0.05), but there were no significant differences between the forth day and the seventh day(all P>0.05).Conclusion Short-term and high-dose of ambroxol in treatment of elderly AECOPD has not only good expectorant effect but also reduces the airway inflammation of AECOPD patients , and it shows a dose-dependent manner .
