中国医药指南
中國醫藥指南
중국의약지남
CHINA MEDICINE GUIDE
2014年
22期
67-69
,共3页
张毓茂%郭玉花%陈晓燕%黄河
張毓茂%郭玉花%陳曉燕%黃河
장육무%곽옥화%진효연%황하
左洛复%丹栀逍遥丸%卒中后抑郁
左洛複%丹梔逍遙汍%卒中後抑鬱
좌락복%단치소요환%졸중후억욱
Zoloft%Danzhixiaoyao pills%Post-stroke depression
目的：观察左洛复联合丹栀逍遥丸治疗卒中后抑郁的疗效与安全性。方法将本院收治的80例卒中后抑郁的患者根据随机原则分为观察组与对照组，每组40例。对照组给予左洛复治疗，观察组在对照组的基础上加用丹栀逍遥丸，治疗8周后，对两组患者的疗效与不良反应进行观察和记录。结果在治疗2、4、6、8周后，观察组的HAMD抑郁量表评分减分率均显著大于对照组，差异有统计学意义（t=4.571、3.317、3.971、3.348，P＜0.05）；治疗8周后，观察组的总有效率为97.5%，显著优于对照组（82.5%），差异具有统计学意义（χ2=5.00， P＜0.05）；观察组的不良反应发生率为7.5%，显著低于对照组（30%），差异具有统计学意义（χ2=6.65，P＜0.05）。结论左洛复联合丹栀逍遥丸治疗卒中后抑郁疗效显著，不良反应少，值得临床推广。
目的：觀察左洛複聯閤丹梔逍遙汍治療卒中後抑鬱的療效與安全性。方法將本院收治的80例卒中後抑鬱的患者根據隨機原則分為觀察組與對照組，每組40例。對照組給予左洛複治療，觀察組在對照組的基礎上加用丹梔逍遙汍，治療8週後，對兩組患者的療效與不良反應進行觀察和記錄。結果在治療2、4、6、8週後，觀察組的HAMD抑鬱量錶評分減分率均顯著大于對照組，差異有統計學意義（t=4.571、3.317、3.971、3.348，P＜0.05）；治療8週後，觀察組的總有效率為97.5%，顯著優于對照組（82.5%），差異具有統計學意義（χ2=5.00， P＜0.05）；觀察組的不良反應髮生率為7.5%，顯著低于對照組（30%），差異具有統計學意義（χ2=6.65，P＜0.05）。結論左洛複聯閤丹梔逍遙汍治療卒中後抑鬱療效顯著，不良反應少，值得臨床推廣。
목적：관찰좌락복연합단치소요환치료졸중후억욱적료효여안전성。방법장본원수치적80례졸중후억욱적환자근거수궤원칙분위관찰조여대조조，매조40례。대조조급여좌락복치료，관찰조재대조조적기출상가용단치소요환，치료8주후，대량조환자적료효여불량반응진행관찰화기록。결과재치료2、4、6、8주후，관찰조적HAMD억욱량표평분감분솔균현저대우대조조，차이유통계학의의（t=4.571、3.317、3.971、3.348，P＜0.05）；치료8주후，관찰조적총유효솔위97.5%，현저우우대조조（82.5%），차이구유통계학의의（χ2=5.00， P＜0.05）；관찰조적불량반응발생솔위7.5%，현저저우대조조（30%），차이구유통계학의의（χ2=6.65，P＜0.05）。결론좌락복연합단치소요환치료졸중후억욱료효현저，불량반응소，치득림상추엄。
Objective To observe the efficacy and safety of Zoloft combined with Danzhixiaoyao pills for the treatment of post-stroke depression. Methods 80 cases of patients with post-stroke depression received in our hospital were randomly divided into observation group and control group, with 40 cases in each group. Control group was given Zoloft, and the observation group was given Danzhixiaoyao pills based on the control group. Efficacy and adverse reactions in the two groups of patients were observed and recorded after 8 weeks of treatment. Results Reduced rate of HAMD scale scores in the observation group 2, 4, 6, 8 weeks after the treatment were significantly higher than the control group, the difference was statistically significant (t=4.571, 3.317, 3.971, 3.348,P<0.05);The total effective rate in observation group was 97.5%after 8 weeks of treatment, significantly better than the control group (82.5%), the difference was statistically significant (χ2=5.00,P<0.05);Adverse reactions rate in observation was 7.5%, significantly lower than the control group (30%), the difference was statistically significant (χ2=6.65,P<0.05). Conclusions Zoloft combined Danzhixiaoyao pills for the treatment of post-stroke depression had significant effect and less adverse reactions, worthy of clinical promotion.
