CAJ | 학술논문

目的：检测慢性乙型肝炎（CHB）患者血清X蛋白含量、HBVDNA、前S1抗原（Pre-S1）、乙型肝炎病毒标志物（HB-VM），探讨他们之间的关系，评估其在HBV感染中的临床价值。方法采用酶联免疫吸附试验（ELISA）检测乙型肝炎患者血清中X蛋白，PreS1；时间分辨法定量测定HBVM，FQ-PCR定量检测HBVDNA。乙型肝炎X蛋白对疾病的影响。结果肝炎组患者的X蛋白阳性率高于健康对照组，肝癌组X蛋白阳性率高于肝炎组，乙型肝炎DNA测定值阳性X蛋白阳性率高于阴性，HBeAg抗原阳性中X蛋白的检出率也高于阴性，并且差异均有统计学意义。结论乙型肝炎X蛋白在疾病监测中有一定的临床意义，并且对病毒的复制有影响。
목적：검측만성을형간염（CHB）환자혈청X단백함량、HBVDNA、전S1항원（Pre-S1）、을형간염병독표지물（HB-VM），탐토타문지간적관계，평고기재HBV감염중적림상개치。방법채용매련면역흡부시험（ELISA）검측을형간염환자혈청중X단백，PreS1；시간분변법정량측정HBVM，FQ-PCR정량검측HBVDNA。을형간염X단백대질병적영향。결과간염조환자적X단백양성솔고우건강대조조，간암조X단백양성솔고우간염조，을형간염DNA측정치양성X단백양성솔고우음성，HBeAg항원양성중X단백적검출솔야고우음성，병차차이균유통계학의의。결론을형간염X단백재질병감측중유일정적림상의의，병차대병독적복제유영향。
Objective To detect the clinical significance of HBV X protein in patients with viral hepatitis B. Detection of HBVDNA, former S1 antigen (Pre-S1), hepatitis B virus markers (HB-VM) of patients, to explore the relationship between them, assess their clinical HBV infection in value. Methods By enzyme-linked immunosorbent assay (ELISA) to detect serum hepatitis BXprotein, PreS1;Time-resolved quantitative determination HBVM, FQ-PCR quantitative detection HBVDNA. HBV X protein on the disease. Results X protein of hepatitis patients was higher in the healthy control group, the group X protein positive rate of liver cancer in hepatitis A, hepatitis B DNA positive X protein was measured value is higher than the negative, HBeAg-positive antigen detection rate in the X protein also higher than the negative, and the differences were statistically significant. Conclusions HBV X protein has clinical significance in disease surveillance, and the replication of the virus affected.