CAJ | 학술논문

目的：通过比较Ⅱ、Ⅲ期乳腺癌改良根治术后常规放疗（CRT）与调强放疗（IMRT）靶区剂量分布和心、肺组织接受的剂量，为临床选择放疗计划提供依据。方法使用TPS治疗计划系统，对100例Ⅱ、Ⅲ期乳腺癌改良根治术后患者分别制定常规放疗与调强放疗计划，比较两种放射治疗计划的剂量分布和心、肺组织的受量。结果 IMRT的V95%明显高于CRT，而IMRT的V105%、V110%明显低于CRT，差异具有统计学意义（P＜0.05），且CRT的HI值较IMRT高，P＜0.05。IMRT中患侧肺V20、V30、V40和左侧乳腺癌患者心脏V30、V40、V50均低于CRT中相应指标，有显著差异（P＜0.05）。结论处方剂量为50 Gy时，调强放疗较常规放疗靶区剂量分布更均匀，且调强放疗还有效地降低了心、肺正常组织的受照剂量和体积。
목적：통과비교Ⅱ、Ⅲ기유선암개량근치술후상규방료（CRT）여조강방료（IMRT）파구제량분포화심、폐조직접수적제량，위림상선택방료계화제공의거。방법사용TPS치료계화계통，대100례Ⅱ、Ⅲ기유선암개량근치술후환자분별제정상규방료여조강방료계화，비교량충방사치료계화적제량분포화심、폐조직적수량。결과 IMRT적V95%명현고우CRT，이IMRT적V105%、V110%명현저우CRT，차이구유통계학의의（P＜0.05），차CRT적HI치교IMRT고，P＜0.05。IMRT중환측폐V20、V30、V40화좌측유선암환자심장V30、V40、V50균저우CRT중상응지표，유현저차이（P＜0.05）。결론처방제량위50 Gy시，조강방료교상규방료파구제량분포경균균，차조강방료환유효지강저료심、폐정상조직적수조제량화체적。
Objective To compare the dose distribution and heart, lung tissue dose of conventional radiotherapy(CRT) with that of the intensity modulation radiation therapy(IMRT) after the postoperative stageⅡandⅢbreast cancer,In order to provide basis for clinical selection of radiotherapy planning. Mehtods The treatment planning system was used to design CRT and IMRT plans for 100 postoperative stageⅡandⅢbreast cancer.By comparison of two kinds of radiotherapy treatment planning dose distribution and heart,lung tissue dose.Results V95%of IMRT was obviously higher than that of CRT and IMRT V105%, V110%obviously lower than that of CRT,the differece is statistically significant(P<0.05).Dose distribution homogeneity indices of CRT was higher than that of IMRT, P<0.05, In IMRT side lung V20, V30, V40, heart V30, V40, V50 of the left side of the breast cancer patients were lower than CRT in the corresponding indicators,there were significant differences(P<0.05).Conclusion With the prescribed dosage as 50Gy,IMRT plan had more uniform dose distribution than CRT plan,and it could effectively reduce the radiation dose for the heart and lungs.