CAJ | 학술논문

目的：分析老年颈内动脉粥样硬化脑梗死患者血清中性粒细胞明胶酶脂质运载蛋白（NGAL）、凝集素样氧化型低密度脂蛋白受体-1（sLox-1）表达及颈动脉内膜改变，探讨其临床意义。方法收集2012年3月至2013年9月在湖南省老年医院神经内科确诊为动脉粥样硬化脑梗死患者70例为A组，颈内动脉粥样硬化患者72例为B组，两组按随机分组法再分为常规治疗组和强化治疗组两个亚组，分别在0周、12周、24周时采用酶联免疫吸附法测定患者血清NGAL、sLox-1水平，并同时测定患者的颈动脉内膜中层厚度和斑块面积，数据结果采用 SPSS 17.0软件进行统计分析。结果脑梗死组患者血清中NGAL和sLox-1的表达水平、颈动脉内膜中层厚度及斑块面积均高于动脉硬化组（P＜0.05），阿托伐他汀治疗24周后强化亚组下降明显（P＜0.05），且颈动脉内膜中层厚度及斑块面积较前降低（ P＜0.05）。结论血清NGAL及sLox-1参与动脉粥样硬化性脑梗死的发生机制，强化调脂治疗后其表达水平下调。
목적：분석노년경내동맥죽양경화뇌경사환자혈청중성립세포명효매지질운재단백（NGAL）、응집소양양화형저밀도지단백수체-1（sLox-1）표체급경동맥내막개변，탐토기림상의의。방법수집2012년3월지2013년9월재호남성노년의원신경내과학진위동맥죽양경화뇌경사환자70례위A조，경내동맥죽양경화환자72례위B조，량조안수궤분조법재분위상규치료조화강화치료조량개아조，분별재0주、12주、24주시채용매련면역흡부법측정환자혈청NGAL、sLox-1수평，병동시측정환자적경동맥내막중층후도화반괴면적，수거결과채용 SPSS 17.0연건진행통계분석。결과뇌경사조환자혈청중NGAL화sLox-1적표체수평、경동맥내막중층후도급반괴면적균고우동맥경화조（P＜0.05），아탁벌타정치료24주후강화아조하강명현（P＜0.05），차경동맥내막중층후도급반괴면적교전강저（ P＜0.05）。결론혈청NGAL급sLox-1삼여동맥죽양경화성뇌경사적발생궤제，강화조지치료후기표체수평하조。
Objective To analyze the neutrophil gelatinase associated lipoclin ( NGAL) and lectin-like oxidized low-density lipoprotein receptor-1 ( sLox-1 ) of the elderly cervical atherosclerosis cerebral infarction patients,and to discuss the clinical significance of the NGAL and sLox-1.Methods Totally 142 cases from March 2012 to September 2013 in the Neurology Department of Geriatric Hospital of Hunan Province were collected in this study , they were divided into two groups , group A ( 70 cases diagnosed of atherosclerosis cerebral infarction ) , group B ( 72 cases with carotid atherosclerosis ) .They were randomly divided into conventional therapy subgroup and intensification therapy subgroup respectively ,on the 0 week, 12 weeks,24 weeks,measure the serum of NGAL and sLox-1 levels,the intimae media thickness(IMT)and the plaque area in patients with ELISA .And the IMT of carotid artery and plaque area were measured , the data were analyzed by SPSS 17.0.Results In cerebral infarction group ,the serum levels of NGAL and sLox-1, the carotid IMT and plaque area were higher than those in the atherosclerosis group (P<0.05),the intensive subgroup decreased significantly by atorvastatin treatment after 24 weeks ( P<0.05 ) , and carotid IMT and plaque area were reduced compared with the previous ( P <0.05 ) .Conclusion The NGAL and sLox-1 participate in the pathogenesis of atherosclerotic cerebral infarction , and the expression are declined with intensive lipid-lowering .