中华脑科疾病与康复杂志(电子版)
中華腦科疾病與康複雜誌(電子版)
중화뇌과질병여강복잡지(전자판)
CHINESE JOURNAL OF BRAIN DI8SEASES AND REHABILITATIN(ELECTRONIC EDITION)
2014年
4期
223-228
,共6页
认知障碍%丁苯酞%简易精神状态评价量表%蒙特利尔认知评估量表
認知障礙%丁苯酞%簡易精神狀態評價量錶%矇特利爾認知評估量錶
인지장애%정분태%간역정신상태평개량표%몽특리이인지평고량표
Cognition disorders%Butylphthalide%Mini-mental state examination%Montreal cognitive assessment scale
目的:观察丁苯酞治疗轻度认知功能障碍( MCI)的疗效,为寻求治疗MCI的有效药物提供临床证据。方法选择135例2011年10月至2012年10月泰安市中心医院神经内科门诊主诉“记忆障碍”就诊的MCI患者,年龄60~80岁,随机分为胞二磷胆碱对照组(67例)和丁苯酞治疗组(68例),胞二磷胆碱对照组给予胞二磷胆碱及肠溶阿司匹林等药物治疗,而丁苯酞治疗组则在常规治疗的基础上加用丁苯酞软胶囊口服,每次0.2 g,每日3次,以3个月为一疗程。3个月后,治疗组完成59例(失访率13.23%),对照组完成57例(失访率14.93%)。两组患者在治疗前及治疗1个月、3个月后均给予简易精神状态评价量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分,以此评价其临床疗效。组内治疗前后比较采用方差分析,组间不良反应比较采用χ2检验。结果治疗组用药1个月、3个月后的MMSE、MoCA评分均高于同期对照组( t值分别为4.690、10.736、3.259、6.623,均P<0.05),且治疗组内3个月后MMSE、MoCA评分高于1个月后( P<0.05),而对照组治疗前及治疗后1个月、3个月的两项评分差异无统计学意义( P>0.05)。两组患者不良反应发生率差异无统计学意义( P>0.05)。结论丁苯酞软胶囊能显著提高MMSE和MoCA评分。丁苯酞软胶囊治疗 MCI有效,能显著改善患者的认知功能,提高其生活质量。
目的:觀察丁苯酞治療輕度認知功能障礙( MCI)的療效,為尋求治療MCI的有效藥物提供臨床證據。方法選擇135例2011年10月至2012年10月泰安市中心醫院神經內科門診主訴“記憶障礙”就診的MCI患者,年齡60~80歲,隨機分為胞二燐膽堿對照組(67例)和丁苯酞治療組(68例),胞二燐膽堿對照組給予胞二燐膽堿及腸溶阿司匹林等藥物治療,而丁苯酞治療組則在常規治療的基礎上加用丁苯酞軟膠囊口服,每次0.2 g,每日3次,以3箇月為一療程。3箇月後,治療組完成59例(失訪率13.23%),對照組完成57例(失訪率14.93%)。兩組患者在治療前及治療1箇月、3箇月後均給予簡易精神狀態評價量錶(MMSE)、矇特利爾認知評估量錶(MoCA)評分,以此評價其臨床療效。組內治療前後比較採用方差分析,組間不良反應比較採用χ2檢驗。結果治療組用藥1箇月、3箇月後的MMSE、MoCA評分均高于同期對照組( t值分彆為4.690、10.736、3.259、6.623,均P<0.05),且治療組內3箇月後MMSE、MoCA評分高于1箇月後( P<0.05),而對照組治療前及治療後1箇月、3箇月的兩項評分差異無統計學意義( P>0.05)。兩組患者不良反應髮生率差異無統計學意義( P>0.05)。結論丁苯酞軟膠囊能顯著提高MMSE和MoCA評分。丁苯酞軟膠囊治療 MCI有效,能顯著改善患者的認知功能,提高其生活質量。
목적:관찰정분태치료경도인지공능장애( MCI)적료효,위심구치료MCI적유효약물제공림상증거。방법선택135례2011년10월지2012년10월태안시중심의원신경내과문진주소“기억장애”취진적MCI환자,년령60~80세,수궤분위포이린담감대조조(67례)화정분태치료조(68례),포이린담감대조조급여포이린담감급장용아사필림등약물치료,이정분태치료조칙재상규치료적기출상가용정분태연효낭구복,매차0.2 g,매일3차,이3개월위일료정。3개월후,치료조완성59례(실방솔13.23%),대조조완성57례(실방솔14.93%)。량조환자재치료전급치료1개월、3개월후균급여간역정신상태평개량표(MMSE)、몽특리이인지평고량표(MoCA)평분,이차평개기림상료효。조내치료전후비교채용방차분석,조간불량반응비교채용χ2검험。결과치료조용약1개월、3개월후적MMSE、MoCA평분균고우동기대조조( t치분별위4.690、10.736、3.259、6.623,균P<0.05),차치료조내3개월후MMSE、MoCA평분고우1개월후( P<0.05),이대조조치료전급치료후1개월、3개월적량항평분차이무통계학의의( P>0.05)。량조환자불량반응발생솔차이무통계학의의( P>0.05)。결론정분태연효낭능현저제고MMSE화MoCA평분。정분태연효낭치료 MCI유효,능현저개선환자적인지공능,제고기생활질량。
Objective To observe the efficacy of butylphthalide in the treatment of patients with mild cognitive impairment(MCI).Methods Within 2 years from October2011 to October 2012,135 cases of out-patients with MCI were randomly divided into conventional treatment group ( 67 cases ) and butylphthalide treatment group ( 68 cases) .In general , both groups were given the same basic treatment of citicoline and aspirin;While patients in the butylphthalide treatment group also took butylphthalide soft capsules by 0.2 g,3 times per day, oral administration with a course of 3 months.After 3 months, the treatment group completed 59 cases(loss of follow-up rate was 13.23%),and the control group completed 57 cases(loss of follow-up rate was 14.93%).All patients were evaluated before therapy and by1 month and 3 months after therapy with mini-mental state examination( MMSE ) and Montreal cognitive assessment scale ( MoCA) .To evaluate the clinical efficacy of butylphthalide , the scale scores from both groups of before treatment,1 month and 3 months after treatment were compared with one-way analysis of variance ,χ2 test was used to compare the adverse reactions between the two groups .Results The MMSE and MoCA scores of butylphthalide group at 1 month,3 months after therapy were significantly higher than that of the control group ( t values were 4.690,10.736 ,3.259 ,6.623 , all P<0.05 ) .Moreover , in the butylphthalide group , MMSE and MoCA scores of the patients after three months therapy was higher than that after one month therapy ( P<0.05 ) ,while there were no significant differences among the scores of baseline and after treatment in the control group ( P>0.05) .There was no stastical significance in the incidence of adverse reaction between the two groups .Conclusion Butylphthalide soft capsule could significantly improve MMSE and MoCA scores of MCI patients.Butylphthalide is effective in the treatment of MCI , which would obviously improve cognitive function and the quality of life of the patients .