CAJ | 학술논문

目的：探讨自然杀伤细胞（NK细胞）在儿童免疫性血小板减少症（ITP）的发病和治疗中的意义。方法采用流式细胞仪分别检测62例新诊断ITP患儿、43例持续性ITP患儿、21例慢性ITP患儿和51例对照组儿童外周血NK细胞百分比；并观察单独使用标准剂量静脉注射用人免疫球蛋白（IVIG）对NK细胞百分比正常及减少的新诊断的ITP患儿的疗效。结果新诊断ITP患儿、持续性ITP、慢性ITP患儿NK细胞百分比均较正常对照组儿童显著降低（P＜0.05），但三组ITP患儿NK细胞百分比差异无显著性（P ！0．05）；NK细胞百分比正常的新诊断ITP患儿单独使用IVIG有效率为92．86％（26/28），NK细胞百分比降低的新诊断ITP患儿单独使用IVIG有效率仅为14．70％（5/34）。结论 NK细胞表达变化与ITP发病存在一定关系，同时NK细胞百分比正常的新诊断ITP患儿可首选IVIG治疗。
목적：탐토자연살상세포（NK세포）재인동면역성혈소판감소증（ITP）적발병화치료중적의의。방법채용류식세포의분별검측62례신진단ITP환인、43례지속성ITP환인、21례만성ITP환인화51례대조조인동외주혈NK세포백분비；병관찰단독사용표준제량정맥주사용인면역구단백（IVIG）대NK세포백분비정상급감소적신진단적ITP환인적료효。결과신진단ITP환인、지속성ITP、만성ITP환인NK세포백분비균교정상대조조인동현저강저（P＜0.05），단삼조ITP환인NK세포백분비차이무현저성（P ！0．05）；NK세포백분비정상적신진단ITP환인단독사용IVIG유효솔위92．86％（26/28），NK세포백분비강저적신진단ITP환인단독사용IVIG유효솔부위14．70％（5/34）。결론 NK세포표체변화여ITP발병존재일정관계，동시NK세포백분비정상적신진단ITP환인가수선IVIG치료。
Objective To explore the significance of natural killer cell(NK)in the pathogenesis and treatment of childhood idiopathic thrombocytopenia(ITP).Methods Peripheral NK cell percentage was teseted by flow cytometry in 62 children with newly diagnosed ITP,43 children with persistent ITP,2 1 children with chronic ITP and 5 1 controls.All the newly diagnosed ITP children were treated with standard dose of intravenous immunoglobulin (IVIG ). Then whether IVIG has a proven impact on the newly diagnosed ITP patients with normal or lower NK cells was observe.Results The percentage of NK cells in children with newly diagnosed ITP,persistent ITP and chronic ITP was all significantly decreased compared with the control group(P<0.05 ).But there was no significant difference among the three groups(P>0.05 ).The efficiency of standard dose of IVIG in newly diagnosed ITP children with normal NK cells and abnormal NK cells was 92.86%(26/28)and 14.70%(5/34)separately.Conclusions NK cell may play role in the pathogenesis of childhood ITP,and standard dose of IVIG is the first choice to treat newly diagnosed ITP children with normal NK cell.