CAJ | 학술논문

在氢氧化钠存在下，白藜芦醇衍生物(E)-2,4-二甲氧基-6-(4-甲氧基苯乙烯基)苯甲醛与丙酮经Claisen-Schmidt缩合反应合成化合物B，收率为77.68%。化合物B和对甲苯磺酰肼在氢氧化钠为缚酸剂，(n-Bu)4NBr为相转移催化剂且用量为化合物B的2 equiv的条件下，于80℃反应12 h，得到产物(E)-3-(2-(4-甲氧基苯乙烯基)-4,6-二甲氧基苯基)-5-甲基-1H-吡唑，收率为59.13%。该方法具有合成成本低、工艺操作简便和经济性好等优点。
재경양화납존재하，백려호순연생물(E)-2,4-이갑양기-6-(4-갑양기분을희기)분갑철여병동경Claisen-Schmidt축합반응합성화합물B，수솔위77.68%。화합물B화대갑분광선정재경양화납위박산제，(n-Bu)4NBr위상전이최화제차용량위화합물B적2 equiv적조건하，우80℃반응12 h，득도산물(E)-3-(2-(4-갑양기분을희기)-4,6-이갑양기분기)-5-갑기-1H-필서，수솔위59.13%。해방법구유합성성본저、공예조작간편화경제성호등우점。
First, compound B was prepared by the Claisen-Schmidt condensation between (E)-2, 4-dimethyl-6-(4-methoxystyryl) benzaldehyde and acetone in the presence of NaOH in 77.68 % yield. Compound C was obtained by the cyclization reaction between compound B and p-Toluenesulfonohydrazide at 80℃for 12 h, using sodium hydroxide as base, (n-Bu)4NBr as phase transfer catalyst and the amount of (n-Bu)4NBr was 2 equiv of compound B. The yield of compound C was 59.13%. The synthetic method had the advantages of low cost, easy to operate and good economy.