CAJ | 학술논문

1.25-二羟维生素D3是维生素D的活性形式，参与机体钙磷代谢、免疫反应、应激、炎症以及肿瘤的调控等。大量研究表明，1.25-二羟维生素D3能与T淋巴细胞、树突状细胞、巨噬细胞等发生作用，通过抗光老化、抑制自身免疫细胞的增生及细胞因子的合成和分泌在炎症性皮肤病、自身免疫性皮肤病及皮肤肿瘤中发挥作用。1.25-二羟维生素D3和类似物将在皮肤病治疗方面发挥重要的作用。
1.25-이간유생소D3시유생소D적활성형식，삼여궤체개린대사、면역반응、응격、염증이급종류적조공등。대량연구표명，1.25-이간유생소D3능여T림파세포、수돌상세포、거서세포등발생작용，통과항광노화、억제자신면역세포적증생급세포인자적합성화분비재염증성피부병、자신면역성피부병급피부종류중발휘작용。1.25-이간유생소D3화유사물장재피부병치료방면발휘중요적작용。
1.25-dihydroxyvitamin D3 is the active form of vitamin D, which is involved in body's calcium and phosphorus metabolism, immune response, stress, inlfammation and regulation of tumors. Numerous studies show that 1.25-dihydroxyvitamin D3 can interact with T lymphocytes, dendritic cells, macrophages and etc, through anti-photoaging, inhibiting of T cell proliferation and cytokines synthesis and secretion, it plays a role in inlfammatory skin diseases, autoimmune skin diseases and skin tumors. 1.25-dihydroxyvitamin D3 and its analogues would play an important role in the treatment of skin diseases.