CAJ | 학술논문

目的：探讨化妆品引起皮肤各种不良反应的状况及远期影响。方法对四川大学华西医院2005-2009年门诊疑为化妆品不良反应的487例患者进行回顾性临床分析，并对接诊后观察时间＞6个月的患者进行随访。结果487例患者以中青年女性居多，临床表现主要为化妆品接触性皮炎（65.3%），化妆品色素异常性皮肤病（10.9%），毛发损害（2.67%），化妆品痤疮（2.5%）。对281例患者行可疑化妆品斑贴试验，73例阳性。对169例进行了随访，87例（51.48%）经过治疗而痊愈，但是仍有近1/4患者症状反复出现，难以痊愈。结论选择化妆品应谨慎，相关卫生行政部门应重视化妆品的安全性监督和管理，各级临床医生对化妆品不良反应及时进行处理，减少并发症。
목적：탐토화장품인기피부각충불량반응적상황급원기영향。방법대사천대학화서의원2005-2009년문진의위화장품불량반응적487례환자진행회고성림상분석，병대접진후관찰시간＞6개월적환자진행수방。결과487례환자이중청년녀성거다，림상표현주요위화장품접촉성피염（65.3%），화장품색소이상성피부병（10.9%），모발손해（2.67%），화장품좌창（2.5%）。대281례환자행가의화장품반첩시험，73례양성。대169례진행료수방，87례（51.48%）경과치료이전유，단시잉유근1/4환자증상반복출현，난이전유。결론선택화장품응근신，상관위생행정부문응중시화장품적안전성감독화관리，각급림상의생대화장품불량반응급시진행처리，감소병발증。
Objective To evaluate adverse reactions and long-term effects caused by cosmetics. Methods A retrospective clinical analysis was carried out on total 487 outpatients suspected to be with cosmetics adverse reactions from 2005 to 2009. The patients with the observation time over six months were followed up. Results Young and middle-aged women were the majority of the patients, and the main clinical manifestations of the adverse reactions were cosmetic contact dermatitis, cosmetic pigment abnormal skin disease, hair damage and cosmetic acne, accounting for 65.3%, 10.9%, 2.67%, 2.5%, respectively. The suspected cosmetic patch tests were given to 281 patients, 73 cases presented positive result. For the 169 patients followed up, 87 patients (51.48%)were cured by treatment, while nearly 25%patients were difficult to cure, symptoms appeared repeatedly. Conclusions Cosmetics should be choosed carefully. The health administrative department should pay more attention to cosmetics safety supervision and management, and all clinicians should process cosmetics adverse reactions in time , so as to reduce the complications.