世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
8期
990-993
,共4页
肺间质纤维化%益气活血%肺痿方%肿瘤标记物CA19-9%临床疗效
肺間質纖維化%益氣活血%肺痿方%腫瘤標記物CA19-9%臨床療效
폐간질섬유화%익기활혈%폐위방%종류표기물CA19-9%림상료효
Pulmonary interstitial fibrosis%Benefiting vital energy and activating blood circulation%Feiwei medicinal instant granules%Clinical curative effect%Tumor markers of CA19-9
目的：观察肺痿冲剂治疗肺间质纤维化的临床疗效及对肿瘤标记物CA19-9的影响。方法：将120例肺间质纤维化患者随机分为治疗组61例、对照组59例，2组患者均进行基础治疗，治疗组同时给予肺痿冲剂方每次100 mL，每日2次口服；对照组给予泼尼松每次30 mg，每日1次口服。治疗2个月后评价2组患者中医证候疗效及患者满意度，并观察2组患者治疗前后中医证候积分、呼吸困难评分、6分钟步行试验、肺功能[包括肺总量（TLC）、用力肺活量（FVC）、一秒用力呼气容积（FEV1）、FEV1/FVC、一氧化碳弥散量（DLCO）]及肿瘤标记物 CA19-9的变化。结果：治疗组与对照组中医证候总有效率分别为62.3％、32.2％，2组比较差异有统计学意义（P＜0.01）。治疗后治疗组中医证候积分、呼吸困难评分、6分钟步行试验、肺功能TLC、FEV1及肿瘤标记物CA19-9均较治疗前改善（P＜0.05或P＜0.01）；对照组中医证候部分指标积分、呼吸困难评分较治疗前改善（P＜0.05或P＜0.01），但肺功能FVC反而较治疗前恶化（P＜0.05）。治疗后治疗组与对照组比较，中医证候部分指标积分、生活质量部分指标评分、6分钟步行试验、肺功能FVC及肿瘤标记物CA19-9差异有统计学意义（P＜0.05或P＜0.01），治疗组疗效优于对照组。结论：肺痿冲剂方治疗肺间质纤维化可减轻患者呼吸困难症状，改善患者生活质量、肺功能。并提示了肺痿冲剂可能有抑制IPF上皮细胞的凋亡及异常增生的作用。
目的：觀察肺痿遲劑治療肺間質纖維化的臨床療效及對腫瘤標記物CA19-9的影響。方法：將120例肺間質纖維化患者隨機分為治療組61例、對照組59例，2組患者均進行基礎治療，治療組同時給予肺痿遲劑方每次100 mL，每日2次口服；對照組給予潑尼鬆每次30 mg，每日1次口服。治療2箇月後評價2組患者中醫證候療效及患者滿意度，併觀察2組患者治療前後中醫證候積分、呼吸睏難評分、6分鐘步行試驗、肺功能[包括肺總量（TLC）、用力肺活量（FVC）、一秒用力呼氣容積（FEV1）、FEV1/FVC、一氧化碳瀰散量（DLCO）]及腫瘤標記物 CA19-9的變化。結果：治療組與對照組中醫證候總有效率分彆為62.3％、32.2％，2組比較差異有統計學意義（P＜0.01）。治療後治療組中醫證候積分、呼吸睏難評分、6分鐘步行試驗、肺功能TLC、FEV1及腫瘤標記物CA19-9均較治療前改善（P＜0.05或P＜0.01）；對照組中醫證候部分指標積分、呼吸睏難評分較治療前改善（P＜0.05或P＜0.01），但肺功能FVC反而較治療前噁化（P＜0.05）。治療後治療組與對照組比較，中醫證候部分指標積分、生活質量部分指標評分、6分鐘步行試驗、肺功能FVC及腫瘤標記物CA19-9差異有統計學意義（P＜0.05或P＜0.01），治療組療效優于對照組。結論：肺痿遲劑方治療肺間質纖維化可減輕患者呼吸睏難癥狀，改善患者生活質量、肺功能。併提示瞭肺痿遲劑可能有抑製IPF上皮細胞的凋亡及異常增生的作用。
목적：관찰폐위충제치료폐간질섬유화적림상료효급대종류표기물CA19-9적영향。방법：장120례폐간질섬유화환자수궤분위치료조61례、대조조59례，2조환자균진행기출치료，치료조동시급여폐위충제방매차100 mL，매일2차구복；대조조급여발니송매차30 mg，매일1차구복。치료2개월후평개2조환자중의증후료효급환자만의도，병관찰2조환자치료전후중의증후적분、호흡곤난평분、6분종보행시험、폐공능[포괄폐총량（TLC）、용력폐활량（FVC）、일초용력호기용적（FEV1）、FEV1/FVC、일양화탄미산량（DLCO）]급종류표기물 CA19-9적변화。결과：치료조여대조조중의증후총유효솔분별위62.3％、32.2％，2조비교차이유통계학의의（P＜0.01）。치료후치료조중의증후적분、호흡곤난평분、6분종보행시험、폐공능TLC、FEV1급종류표기물CA19-9균교치료전개선（P＜0.05혹P＜0.01）；대조조중의증후부분지표적분、호흡곤난평분교치료전개선（P＜0.05혹P＜0.01），단폐공능FVC반이교치료전악화（P＜0.05）。치료후치료조여대조조비교，중의증후부분지표적분、생활질량부분지표평분、6분종보행시험、폐공능FVC급종류표기물CA19-9차이유통계학의의（P＜0.05혹P＜0.01），치료조료효우우대조조。결론：폐위충제방치료폐간질섬유화가감경환자호흡곤난증상，개선환자생활질량、폐공능。병제시료폐위충제가능유억제IPF상피세포적조망급이상증생적작용。
Objective:To observe the curative effect of the Feiwei medicinal instant granules on pulmonary interstitial fibrosis and effect on tumor markers of CA19-9.Methods:One hundred and twenty patients with pulmonary interstitial fibrosis were randomly divided into treatment group (n=61)and control group (n=59),and all of them were given fundamental treatment.Patients in the treatment group also received oral administration of Feiwei medicinal instant granules for consumptive lung disease twice a day,100ml a time.Patients in the control group were given oral administration of prednisone once a day,30mg each time.After 2 months of treatment,a series of chan-ges of the two groups before and after the treatment,including:TCM score,dyspnea scores,six-minutes walking test,TLC,FVC,FEV1 , FEV1/FVC,DLCO and tumor markers of CA19-9 were observed.Results:The total effective rates of TCMsyndrome in treatment group and control group were respectively 61.7% and 34.8%,and there was significant difference between the two groups.In the treatment group,TCM score,dyspnea scores,six-minutes walking test,TLC,FEV1 ,and tumor markers of CA19 -9 were improved obviously(P<0.05 or P<0.01).In the control group,the part of TCMscore,dyspnea scores were relatively improved,too(P<0.05).However,the treatment group was superior to control group in the improvement of TCM syndromes,dyspnea scores,six-minutes walking test,FVC and tumor markers of CA19-9.Conclusion:Feiwei medicinal instant granules can effectively relieve the symptoms of dyspnea in patients with pulmonary interstitial fibrosis,increase exercise tolerance,enhance the TLC,FEV1 in lung function,and bring patients more satisfac-tion.The medicinal instant granules may inhibit apoptosis of epithelial cells of IPF and abnormal proliferation.
