世界中医药
世界中醫藥
세계중의약
WORLD CHINESE MEDICINE
2014年
8期
978-982
,共5页
于洋%韩春生%韩桂玲%张纾难
于洋%韓春生%韓桂玲%張紓難
우양%한춘생%한계령%장서난
生存分析%特发性肺纤维化%预后因素%中医
生存分析%特髮性肺纖維化%預後因素%中醫
생존분석%특발성폐섬유화%예후인소%중의
Survival analysis%Idiopathic pulmonary fibrosis%Prognostic factors%Traditional Chinese medicine
目的:探讨临床相关指标、肺组织病生理变化、中医证候积分等因素对特发性肺纤维化(IPF)患者预后的影响价值。方法:经临床诊断的48例IPF患者行呼吸困难评分、肺功能和动脉血气检测。采用Kaplan-Meier检验比较组间生存率,采用Cox比例风险回归评价各指标的死亡风险度。结果:在平均随访37个月内,IPF患者诊断后的中位生存期为37.35个月。单因素Cox比例风险回归分析提示:中医证候积分、体重指数、6分钟步行试验、肺功能中的FVC%、TLC%、DLCO%、血气分析中的PO2、血沉、杵状指是影响特发性肺纤维化患者预后的因素(P<0.05);多因素Cox比例风险回归分析显示:体重指数、6分钟步行试验、血沉是IPF患者预后的主要影响因素。结论:体重指数、中医证候积分、6分钟步行试验、肺功能中TLC%、DLCO%、血气分析中PO2、血沉、杵状指是IPF患者预后的影响因素,其中体重指数、6分钟步行试验、血沉是主要影响因素。
目的:探討臨床相關指標、肺組織病生理變化、中醫證候積分等因素對特髮性肺纖維化(IPF)患者預後的影響價值。方法:經臨床診斷的48例IPF患者行呼吸睏難評分、肺功能和動脈血氣檢測。採用Kaplan-Meier檢驗比較組間生存率,採用Cox比例風險迴歸評價各指標的死亡風險度。結果:在平均隨訪37箇月內,IPF患者診斷後的中位生存期為37.35箇月。單因素Cox比例風險迴歸分析提示:中醫證候積分、體重指數、6分鐘步行試驗、肺功能中的FVC%、TLC%、DLCO%、血氣分析中的PO2、血沉、杵狀指是影響特髮性肺纖維化患者預後的因素(P<0.05);多因素Cox比例風險迴歸分析顯示:體重指數、6分鐘步行試驗、血沉是IPF患者預後的主要影響因素。結論:體重指數、中醫證候積分、6分鐘步行試驗、肺功能中TLC%、DLCO%、血氣分析中PO2、血沉、杵狀指是IPF患者預後的影響因素,其中體重指數、6分鐘步行試驗、血沉是主要影響因素。
목적:탐토림상상관지표、폐조직병생리변화、중의증후적분등인소대특발성폐섬유화(IPF)환자예후적영향개치。방법:경림상진단적48례IPF환자행호흡곤난평분、폐공능화동맥혈기검측。채용Kaplan-Meier검험비교조간생존솔,채용Cox비례풍험회귀평개각지표적사망풍험도。결과:재평균수방37개월내,IPF환자진단후적중위생존기위37.35개월。단인소Cox비례풍험회귀분석제시:중의증후적분、체중지수、6분종보행시험、폐공능중적FVC%、TLC%、DLCO%、혈기분석중적PO2、혈침、저상지시영향특발성폐섬유화환자예후적인소(P<0.05);다인소Cox비례풍험회귀분석현시:체중지수、6분종보행시험、혈침시IPF환자예후적주요영향인소。결론:체중지수、중의증후적분、6분종보행시험、폐공능중TLC%、DLCO%、혈기분석중PO2、혈침、저상지시IPF환자예후적영향인소,기중체중지수、6분종보행시험、혈침시주요영향인소。
Objective:To investigate effects of relevant factors including clinical implications,lung disease and physiological variables and TCM syndrome integral on the prognosis of patients with idiopathic pulmonary fibrosis (IPF).Methods:Forty-eight patients with IPF according to clinical diagnosis underwent dyspnea score,pulmonary function tests and arterial blood gas test.The Kaplan-Meier test was used to estimate the survival rate in the two groups,and Coxproportional hazard regression was taken to evaluate Hazard Ratio in the IPF patients.Results:During the37 months of follow-up,the median survival time was 37.35 months after diagnosis.The univariate Cox pro-portional hazards regression analysis showed that TCMsyndrome integral,BMI,6 minutes walk test and FVC%,TLC%,DLCO%,PO2, ESR,clubbing fingers were the factors affected the prognosis of patients with IPF (P<0.05 ).The multivariate Cox proportional hazards regression analysis showed that BMI,6 minutes walk test,ESR were the main influence factors for the prognosis of patients with IPF.Con-clusion:BMI,TCM syndrome integral,6 minutes walk test and TLC %,DLCO %,PO2 ,ESR,clubbing fingers were the influence factors of the prognosis of patients with IPF,among which the BMI,6 minutes walk test,ESR were the main influence factors.